Ex vivo determination of glucose permeability and optical attenuation   coefficient in normal and adenomatous human colon tissues using spectral   domain optical coherence tomography

doi:10.1117/1.JBO.17.10.105004

CORC > 北京大学 > 工学院

	Ex vivo determination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography
	Zhao, Qingliang ; Zhou, Chuanqing ; Wei, Huajiang ; He, Yonghong ; Chai, Xinyu ; Ren, Qiushi
刊名	生物医学光学通讯
	2012
关键词	permeability coefficient glucose attenuation coefficient colon adenocarcinoma spectral domain optical coherence tomography SCATTERING MEDIA CHEMICAL-AGENTS IN-VITRO DIFFUSION QUANTIFICATION CANCER COLLAGEN
DOI	10.1117/1.JBO.17.10.105004
英文摘要	Recent reports have suggested that spectral domain optical coherence tomography (SD-OCT) is a useful tool for quantifying the permeability of hyperosmotic agents in various tissues. We report our preliminary results on quantification of glucose diffusion and assessment of the optical attenuation change due to the diffusion of glucose in normal and adenomatous human colon tissues in vitro by using a SD-OCT and then calculated the permeability coefficients (PC) and optical attenuation coefficients (AC). The PC of a 30% aqueous solution of glucose was 3.37 +/- 0.23 x 10(-6) cm/s in normal tissue and 5.65 +/- 0.16 x 10(-6) cm/s in cancerous colon tissue. Optical AC in a normal colon ranged from 3.48 +/- 0.37 to 2.68 +/- 0.82 mm(-1) and was significantly lower than those seen in the cancerous tissue (8.48 +/- 0.95 to 3.16 +/- 0.69 mm(-1), p < 0.05). The results suggest that quantitative measurements of using PC and AC from OCT images could be a potentially powerful method for colon cancer detection. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.10.105004]; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000309910700024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging; SCI(E); EI; 6; ARTICLE; 10; 17
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/392828]
专题	工学院
推荐引用方式 GB/T 7714	Zhao, Qingliang,Zhou, Chuanqing,Wei, Huajiang,et al. Ex vivo determination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography[J]. 生物医学光学通讯,2012.
APA	Zhao, Qingliang,Zhou, Chuanqing,Wei, Huajiang,He, Yonghong,Chai, Xinyu,&Ren, Qiushi.(2012).Ex vivo determination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography.生物医学光学通讯.
MLA	Zhao, Qingliang,et al."Ex vivo determination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography".生物医学光学通讯 (2012).