Electrical stimulation with a penetrating optic nerve electrode array   elicits visuotopic cortical responses in cats

doi:10.1088/1741-2560/10/3/036022

CORC > 北京大学 > 工学院

	Electrical stimulation with a penetrating optic nerve electrode array elicits visuotopic cortical responses in cats
	Lu, Yiliang ; Yan, Yan ; Chai, Xinyu ; Ren, Qiushi ; Chen, Yao ; Li, Liming
刊名	journal of neural engineering
	2013
关键词	VISUAL-CORTEX RETINITIS-PIGMENTOSA EVOKED-POTENTIALS STRIATE CORTEX FELINE RETINA BLIND HUMANS RABBIT EYES PROSTHESIS MICROSTIMULATION IMPLANTATION
DOI	10.1088/1741-2560/10/3/036022
英文摘要	Objective. A visual prosthesis based on penetrating electrode stimulation within the optic nerve (ON) is a potential way to restore partial functional vision for blind patients. We investigated the retinotopic organization of ON stimulation and its spatial resolution. Approach. A five-electrode array was inserted perpendicularly into the ON or a single electrode was advanced to different depths within the ON (similar to 1-2 mm behind the eyeball, 13 cats). A sparse noise method was used to map ON electrode position and the visual cortex. Cortical responses were recorded by a 5 x 6 array. The visuotopic correspondence between the retinotopic position of the ON electrode was compared with the visual evoked cortical map and the electrical evoked potentials elicited in response to ON stimulation. Main results. Electrical stimulation with penetrating ON electrodes elicited cortical responses in visuotopographically corresponding areas of the cortex. Stimulation of the temporal side of the ON elicited cortical responses corresponding to the central visual field. The visual field position shifted from the lower to central visual field as the electrode penetrated through the depth of the ON. A spatial resolution of similar to 2 degrees to 3 degrees within a limited cortical visuotopic representation could be obtained by this approach. Significance. Visuotopic electrical stimulation with a relatively fine spatial resolution can be accomplished using penetrating electrodes implanted at multiple sites and at different depths within the ON just behind the globe. This study also provides useful experimental data for the design of electrode density and the distribution of penetrating ON electrodes for a visual prosthesis.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319510800025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Biomedical; Neurosciences; SCI(E); EI; 8; ARTICLE; 3; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/391496]
专题	工学院
推荐引用方式 GB/T 7714	Lu, Yiliang,Yan, Yan,Chai, Xinyu,et al. Electrical stimulation with a penetrating optic nerve electrode array elicits visuotopic cortical responses in cats[J]. journal of neural engineering,2013.
APA	Lu, Yiliang,Yan, Yan,Chai, Xinyu,Ren, Qiushi,Chen, Yao,&Li, Liming.(2013).Electrical stimulation with a penetrating optic nerve electrode array elicits visuotopic cortical responses in cats.journal of neural engineering.
MLA	Lu, Yiliang,et al."Electrical stimulation with a penetrating optic nerve electrode array elicits visuotopic cortical responses in cats".journal of neural engineering (2013).