Engineering imaging probes and molecular machines for nanomedicine

doi:10.1007/s11427-012-4380-1

CORC > 北京大学 > 工学院

	Engineering imaging probes and molecular machines for nanomedicine
	Tong Sheng ; Cradick, Thomas J. ; Ma Yan ; Dai ZhiFei ; Bao Gang
刊名	science china life sciences
	2012
关键词	nanomedicine imaging probe contrast agent drug delivery designer nuclease RESONANCE ENERGY-TRANSFER RAY COMPUTED-TOMOGRAPHY IRON-OXIDE NANOPARTICLES SEMICONDUCTOR QUANTUM DOTS LARGE-SCALE SYNTHESIS BISMUTH SULFIDE NANOPARTICLES MESSENGER-RNA DETECTION HUMAN LEUKEMIA-CELLS SENTINEL LYMPH-NODE REAL-TIME DETECTION
DOI	10.1007/s11427-012-4380-1
英文摘要	Nanomedicine is an emerging field that integrates nanotechnology, biomolecular engineering, life sciences and medicine; it is expected to produce major breakthroughs in medical diagnostics and therapeutics. Due to the size-compatibility of nano-scale structures and devices with proteins and nucleic acids, the design, synthesis and application of nanoprobes, nanocarriers and nanomachines provide unprecedented opportunities for achieving a better control of biological processes, and drastic improvements in disease detection, therapy, and prevention. Recent advances in nanomedicine include the development of functional nanoparticle based molecular imaging probes, nano-structured materials as drug/gene carriers for in vivo delivery, and engineered molecular machines for treating single-gene disorders. This review focuses on the development of molecular imaging probes and engineered nucleases for nanomedicine, including quantum dot bioconjugates, quantum dot-fluorescent protein FRET probes, molecular beacons, magnetic and gold nanoparticle based imaging contrast agents, and the design and validation of zinc finger nucleases (ZFNs) and TAL effector nucleases (TALENs) for gene targeting. The challenges in translating nanomedicine approaches to clinical applications are discussed.; Biology; SCI(E); 4; REVIEW; 10; 843-861; 55
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/230880]
专题	工学院
推荐引用方式 GB/T 7714	Tong Sheng,Cradick, Thomas J.,Ma Yan,et al. Engineering imaging probes and molecular machines for nanomedicine[J]. science china life sciences,2012.
APA	Tong Sheng,Cradick, Thomas J.,Ma Yan,Dai ZhiFei,&Bao Gang.(2012).Engineering imaging probes and molecular machines for nanomedicine.science china life sciences.
MLA	Tong Sheng,et al."Engineering imaging probes and molecular machines for nanomedicine".science china life sciences (2012).