In vitro Biocompatibility of a Platinum-Electrode Embedded   Photosensitive Polyimide (Durimide) Retinal Prosthesis

doi:10.3109/02713683.2012.702842

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	In vitro Biocompatibility of a Platinum-Electrode Embedded Photosensitive Polyimide (Durimide) Retinal Prosthesis
	Liu, Wenjia ; Song, ZhengYu ; Mo, Yanan ; Wang, Weijun ; Sui, Xiaohong ; Gong, Yuanyuan ; Jiang, Yuan ; Zhang, Lei ; Huang, Jiannan ; Gu, Qing ; Li, Gang ; Zhou, Chuanqing ; Yu, Zhang ; Ren, Qiushi ; Sun, Xiaodong ; Wang, Fenghua
刊名	current eye research
	2012
关键词	Biocompatibility Retinal prosthesis Cytotoxicity Durimide SUPRACHOROIDAL-TRANSRETINAL STIMULATION OPTIC-NERVE STIMULATION RETINITIS-PIGMENTOSA ARRAY MICROELECTRONICS FEASIBILITY VISION BLIND
DOI	10.3109/02713683.2012.702842
英文摘要	Purpose: The photosensitive polyimide film, Durimide, is a common component of retinal prostheses; however, retinal cell response to Durimide has not been effectively studied This work assessed the in vitro biocompatibility of a retinal prosthesis containing platinum-electrode embedded Durimide film. Materials and methods: Biocompatibility evaluation assessed cytotoxicity, attachment, and proliferation of two cell lines: a human retinal pigmented epithelium cell line (CRL) and a rhesus monkey choroid-retinal endothelial cell line (RF/6A). Cells were cultured with the platinum-electrode embedded Durimide film, with tissue-culture treated polystyrene plates (TCPS) used as a control substrate for cell growth. The effect of a Durimide-exposed medium on cell apoptosis and life cycle was assessed using flow cytometry (FCM). Results: The indirect cytotoxicity evaluation revealed no toxic effect of the prosthesis on cells. The attachment and proliferation of CRL and RF/6A cells cultured with the Durimide prostheses showed no significant differences to the control. The FCM experiments demonstrated a liquid medium exposed to the prosthesis had no effects on apoptosis or cell life cycle in comparison with the control (p > 0.05). Conclusions: The results demonstrate that Durimide has good biocompatibility with retinal cell lines CRL and RF/6A. In conclusion, while further in vitro and in vivo studies are required to clarify long-term effects, Durimide is indicated as a promising material with suitable biocompatibility for retinal implants.; Ophthalmology; SCI(E); 0; ARTICLE; 11; 1036-1044; 37
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/229483]
专题	工学院
推荐引用方式 GB/T 7714	Liu, Wenjia,Song, ZhengYu,Mo, Yanan,et al. In vitro Biocompatibility of a Platinum-Electrode Embedded Photosensitive Polyimide (Durimide) Retinal Prosthesis[J]. current eye research,2012.
APA	Liu, Wenjia.,Song, ZhengYu.,Mo, Yanan.,Wang, Weijun.,Sui, Xiaohong.,...&Wang, Fenghua.(2012).In vitro Biocompatibility of a Platinum-Electrode Embedded Photosensitive Polyimide (Durimide) Retinal Prosthesis.current eye research.
MLA	Liu, Wenjia,et al."In vitro Biocompatibility of a Platinum-Electrode Embedded Photosensitive Polyimide (Durimide) Retinal Prosthesis".current eye research (2012).