Evaluation of a MEMS-Based Dual Metal-Layer Thin-Film Microelectrode   Array for Suprachoroidal Electrical Stimulation

doi:10.1109/TNSRE.2012.2188042

CORC > 北京大学 > 工学院

	Evaluation of a MEMS-Based Dual Metal-Layer Thin-Film Microelectrode Array for Suprachoroidal Electrical Stimulation
	Sui, Xiaohong ; Sun, Jingjing ; Li, Liming ; Zhou, Chuanqing ; Luo, Xuejiao ; Xia, Niansheng ; Yan, Yan ; Chen, Yao ; Ren, Qiushi ; Chai, Xinyu
刊名	ieee transactions on neural systems and rehabilitation engineering
	2013
关键词	Electrically evoked potentials microelectrode polyimide film suprachoroidal implantation visual prosthesis TRANSRETINAL STIMULATION RABBIT EYES MULTICHANNEL ELECTRODE DISSOLUTION PROSTHESIS RETINA
DOI	10.1109/TNSRE.2012.2188042
英文摘要	A double metal-layer thin-film platinum microelectrode array was fabricated for implantation between sclera and choroid based on MEMS processing techniques and photosensitive polyimide material. The array was composed of 60 stimulating sites (6 x 10) and four selectable returning electrodes. The diameter of each stimulating electrode was 350 mu m with a center-to-center spacing of 750 mu m. The transient voltage responses of the electrode to current pulse stimulation indicated a charge-injection capacity greater than 52.1 mu C/cm(2) . Acute in vivo animal experiments showed that the implicit time of electrically evoked potentials (EEPs) was 17.09 +/- 1.45 ms at a threshold current of 25.55 +/- 5.43 mu A for a full-row of simultaneously stimulated electrodes (i.e., current applied simultaneously to each of the 10 electrodes). Individual electrode stimulation threshold was 48.57 +/- 6.90 mu A. The corresponding threshold charge densities were 13.28 +/- 2.82 mu C/cm(2) and 25.24 +/- 3.59 mu C/cm(2) , respectively. The spatial spread of the maximally recorded P1 response in the EEPs indicated a correspondence between the retinal stimulation site and the focal response location in the cortex. This method of array fabrication is suitable for acute suprachoroidal stimulation, and has a potential use for the fabrication of a visual prosthesis.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000321737000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Biomedical; Rehabilitation; SCI(E); EI; 3; ARTICLE; 4; 524-531; 21
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/222158]
专题	工学院
推荐引用方式 GB/T 7714	Sui, Xiaohong,Sun, Jingjing,Li, Liming,et al. Evaluation of a MEMS-Based Dual Metal-Layer Thin-Film Microelectrode Array for Suprachoroidal Electrical Stimulation[J]. ieee transactions on neural systems and rehabilitation engineering,2013.
APA	Sui, Xiaohong.,Sun, Jingjing.,Li, Liming.,Zhou, Chuanqing.,Luo, Xuejiao.,...&Chai, Xinyu.(2013).Evaluation of a MEMS-Based Dual Metal-Layer Thin-Film Microelectrode Array for Suprachoroidal Electrical Stimulation.ieee transactions on neural systems and rehabilitation engineering.
MLA	Sui, Xiaohong,et al."Evaluation of a MEMS-Based Dual Metal-Layer Thin-Film Microelectrode Array for Suprachoroidal Electrical Stimulation".ieee transactions on neural systems and rehabilitation engineering (2013).