Biologically Derived Soft Conducting Hydrogels Using Heparin-Doped   Polymer Networks

doi:10.1021/nn406019m

CORC > 北京大学 > 工学院

	Biologically Derived Soft Conducting Hydrogels Using Heparin-Doped Polymer Networks
	Ding, Hangjun ; Zhong, Mingjiang ; Kim, Young Jo ; Pholpabu, Pitirat ; Balasubramanian, Aditya ; Hui, Chin Ming ; He, Hongkun ; Yang, Huai ; Matyjaszewski, Krzysztof ; Bettinger, Christopher John
刊名	acs nano
	2014
关键词	hydrogel polymer biomaterial electronically active NEURAL INTERFACES BIOMEDICAL APPLICATIONS ELECTRICAL-CONDUCTIVITY POLYANILINE NANOTUBES LARGE-AREA ELECTRODES FILMS SUPERCAPACITORS TRANSISTORS PERFORMANCE
DOI	10.1021/nn406019m
英文摘要	The emergence of flexible and stretchable electronic components expands the range of applications of electronic devices. Flexible devices are ideally suited for electronic biointerfaces because of mechanically permissive structures that conform to curvilinear structures found in native tissue. Most electronic materials used in these applications exhibit elastic moduli on the order of 0.1-1 MPa. However, many electronically excitable tissues exhibit elasticities in the range of 1-10 kPa, several orders of magnitude smaller than existing components used in flexible devices. This work describes the use of biologically derived heparins as scaffold materials for fabricating networks with hybrid electronic/ionic conductivity and ultracompliant mechanical properties. Photo-cross-linkable heparin methacrylate hydrogels serve as templates to control the microstructure and doping of in situ polymerized polyaniline structures. Macroscopic heparin-doped polyaniline hydrogel dual networks exhibit impedances as low as Z = 4.17 Omega at 1 kHz and storage moduli of G' = 900 +/- 100 Pa. The conductivity of heparin/polyaniline networks depends on the oxidation state and microstructure of secondary polyaniline networks. Furthermore, heparin/polyaniline networks support the attachment, proliferation, and differentiation of mu rifle myoblasts without any surface treatments. Taken together, these results suggest that heparin/polyaniline hydrogel networks exhibit suitable physical properties as an electronically active biointerface material that can match the mechanical properties of soft tissues composed of excitable cells.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336640600025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; SCI(E); EI; 8; ARTICLE; km3b@andrew.cmu.edu; cbetting@andrew.cmu.edu; 5; 4348-4357; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/213024]
专题	工学院
推荐引用方式 GB/T 7714	Ding, Hangjun,Zhong, Mingjiang,Kim, Young Jo,et al. Biologically Derived Soft Conducting Hydrogels Using Heparin-Doped Polymer Networks[J]. acs nano,2014.
APA	Ding, Hangjun.,Zhong, Mingjiang.,Kim, Young Jo.,Pholpabu, Pitirat.,Balasubramanian, Aditya.,...&Bettinger, Christopher John.(2014).Biologically Derived Soft Conducting Hydrogels Using Heparin-Doped Polymer Networks.acs nano.
MLA	Ding, Hangjun,et al."Biologically Derived Soft Conducting Hydrogels Using Heparin-Doped Polymer Networks".acs nano (2014).