Photoprotective Effects of Oxyresveratrol and Kuwanon Os on DNA Damage   Induced by UVA in Human Epidermal Keratinocytes

doi:10.1021/tx500497u

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	Photoprotective Effects of Oxyresveratrol and Kuwanon Os on DNA Damage Induced by UVA in Human Epidermal Keratinocytes
	Hu, Shuting ; Chen, Feng ; Wang, Mingfu
刊名	毒物学领域的化学研究
	2015
关键词	NUCLEOTIDE EXCISION-REPAIR OXIDATIVE STRESS HACAT KERATINOCYTES REACTIVE OXYGEN NITRIC-OXIDE HUMAN SKIN CANCER ANTIOXIDANT POLYPHENOLS RADIATION
DOI	10.1021/tx500497u
英文摘要	Ultraviolet A not only plays a major part in photoaging and skin tanning but also induces genetic damage and mutation in the epidermal basal layer of human skin. The photoprotective effect of oxyresveratrol and kuwanon O, two phenolic compounds from the root extract of Morus australis, in human primly epidermal keratinocytes was investigated in this study. Both of them were nontoxic to cells at a concentration less than 10 and 0.5 mu M, respectively. After pretreatment at the concentrations of 5 and 10 mu M, oxyresveratrol increased cell viability, exhibited significant suppressions on UVA- or H2O2 induced cellular ROS. UVA-enhanced nitrotyrosine was also reduced by post-treatment with oxyresveratrol at theses concentrations. Kuwanon O presented similar inhibitions on cellular ROS and nitrotyrosine with lower concentrations (0.25 and 0.5 mu M), but there is no significant protection on cell survival after UVA irradiation. Their photoprotective effects also involved the enhanced repair of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and cydobutane pyrimidine dimers (CPDs) as mediated by the augment of p53 expression after UVA radiation.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000351326400029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology; SCI(E); 3; ARTICLE; mfwang@hku.hk; 3,SI; 541-548; 28
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/206089]
专题	工学院
推荐引用方式 GB/T 7714	Hu, Shuting,Chen, Feng,Wang, Mingfu. Photoprotective Effects of Oxyresveratrol and Kuwanon Os on DNA Damage Induced by UVA in Human Epidermal Keratinocytes[J]. 毒物学领域的化学研究,2015.
APA	Hu, Shuting,Chen, Feng,&Wang, Mingfu.(2015).Photoprotective Effects of Oxyresveratrol and Kuwanon Os on DNA Damage Induced by UVA in Human Epidermal Keratinocytes.毒物学领域的化学研究.
MLA	Hu, Shuting,et al."Photoprotective Effects of Oxyresveratrol and Kuwanon Os on DNA Damage Induced by UVA in Human Epidermal Keratinocytes".毒物学领域的化学研究 (2015).