Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a   Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance   Imaging Guided Photothermal Tumor Ablation

doi:10.7150/thno.7275

CORC > 北京大学 > 工学院

	Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation
	Ke, Hengte ; Wang, Jinrui ; Tong, Sheng ; Jin, Yushen ; Wang, Shumin ; Qu, Enze ; Bao, Gang ; Dai, Zhifei
刊名	theranostics
	2014
关键词	Liquid perfluorocarbon nanocapules Superparamagnetic iron oxide nanoparticles Gold nanoshell Bimodal imaging Photothermal therapy IRON-OXIDE NANOPARTICLES MACROPHAGE ENDOCYTOSIS CANCER-THERAPY IN-VIVO SURFACES SURGERY AGENTS MRI
DOI	10.7150/thno.7275
英文摘要	Imaging guided ablation therapy has been applied in both biomedical research and clinical trials and turned out to be one of the most promising approaches for cancer treatment. Herein, the multifunctional nanocapsules were fabricated through loading perfluorooctylbromide (PFOB) and superparamagnetic iron oxide nanoparticles (SPIOs) into poly(lactic acid) (PLA) nanocapsules (NCs), followed by the formation of PEGylated gold nanoshell on the surface. The resulting multi-component NCs were proved to be able to act as nanotheranostic agent to achieve successful bimodal ultrasound (US)/magnetic resonance imaging (MRI) guided photothermal ablation in human tumor xenograft models non-invasively. Such a single theranostic agent with the combination of real-time US and high-resolution MR imaging would be of great value to offer more comprehensive diagnostic information and dynamics of disease progression for the accurate location of therapeutic focusing spot in the targeted tumor tissue, showing great potential as an effective nanoplatform for contrast imaging guided photothermal therapy.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000331402100002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Medicine, Research & Experimental; SCI(E); PubMed; 30; ARTICLE; zhifei.dai@pku.edu.cn; 1; 12-23; 4
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189655]
专题	工学院
推荐引用方式 GB/T 7714	Ke, Hengte,Wang, Jinrui,Tong, Sheng,et al. Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation[J]. theranostics,2014.
APA	Ke, Hengte.,Wang, Jinrui.,Tong, Sheng.,Jin, Yushen.,Wang, Shumin.,...&Dai, Zhifei.(2014).Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation.theranostics.
MLA	Ke, Hengte,et al."Gold Nanoshelled Liquid Perfluorocarbon Magnetic Nanocapsules: a Nanotheranostic Platform for Bimodal Ultrasound/Magnetic Resonance Imaging Guided Photothermal Tumor Ablation".theranostics (2014).