Effect of the addition of low rare earth elements (lanthanum, neodymium,   cerium) on the biodegradation and biocompatibility of magnesium

doi:10.1016/j.actbio.2014.09.041

CORC > 北京大学 > 工学院

	Effect of the addition of low rare earth elements (lanthanum, neodymium, cerium) on the biodegradation and biocompatibility of magnesium
	Willbold, Elmar ; Gu, Xuenan ; Albert, Devon ; Kalla, Katharina ; Bobe, Katharina ; Brauneis, Maria ; Janning, Carla ; Nellesen, Jens ; Czayka, Wolfgang ; Tillmann, Wolfgang ; Zheng, Yufeng ; Witte, Frank
刊名	acta biomaterialia
	2015
关键词	Magnesium alloy Rare earth elements Biocompatibility Biodegradable implants In vitro IN-VIVO-DEGRADATION CORROSION-RESISTANCE BINARY-ALLOYS BONE-IMPLANT BIOMATERIALS VITRO BEHAVIOR MICROSTRUCTURE PROLIFERATION IMPROVEMENT
DOI	10.1016/j.actbio.2014.09.041
英文摘要	Rare earth elements are promising alloying element candidates for magnesium alloys used as biodegradable devices in biomedical applications. Rare earth elements have significant effects on the high temperature strength as well as the creep resistance of alloys and they improve magnesium corrosion resistance. We focused on lanthanum, neodymium and cerium to produce magnesium alloys with commonly used rare earth element concentrations. We showed that low concentrations of rare earth elements do not promote bone growth inside a 750 mu m broad area around the implant. However, increased bone growth was observed at a greater distance from the degrading alloys. Clinically and histologically, the alloys and their corrosion products caused no systematic or local cytotoxicological effects. Using microtomography and in vitro experiments, we could show that the magnesium-rare earth element alloys showed low corrosion rates, both in in vitro and in vivo. The lanthanum- and cerium-containing alloys degraded at comparable rates, whereas the neodymium-containing alloy showed the lowest corrosion rates. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.; Engineering, Biomedical; Materials Science, Biomaterials; SCI(E); PubMed; 1; ARTICLE; yfzheng@pku.edu.cn; frank.witte@charite.de; 554-562; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189065]
专题	工学院
推荐引用方式 GB/T 7714	Willbold, Elmar,Gu, Xuenan,Albert, Devon,et al. Effect of the addition of low rare earth elements (lanthanum, neodymium, cerium) on the biodegradation and biocompatibility of magnesium[J]. acta biomaterialia,2015.
APA	Willbold, Elmar.,Gu, Xuenan.,Albert, Devon.,Kalla, Katharina.,Bobe, Katharina.,...&Witte, Frank.(2015).Effect of the addition of low rare earth elements (lanthanum, neodymium, cerium) on the biodegradation and biocompatibility of magnesium.acta biomaterialia.
MLA	Willbold, Elmar,et al."Effect of the addition of low rare earth elements (lanthanum, neodymium, cerium) on the biodegradation and biocompatibility of magnesium".acta biomaterialia (2015).