HIP-55 negatively regulates myocardial contractility at the single-cell   level

doi:10.1016/j.jbiomech.2014.05.003

CORC > 北京大学 > 工学院

	HIP-55 negatively regulates myocardial contractility at the single-cell level
	Xing, Rui ; Li, Shanshan ; Liu, Kai ; Yuan, Yuan ; Li, Qing ; Deng, Hao ; Yang, Chengzhi ; Huang, Jianyong ; Zhang, Youyi ; Fang, Jing ; Xiong, Chunyang ; Li, Zijian
刊名	journal of biomechanics
	2014
关键词	HIP-55 Myocardial contractility Traction force microscopy HEART-FAILURE ADAPTER PROTEIN MAMMALIAN ABP1 DIFFERENTIATION CYTOSKELETON HYPERTROPHY RECEPTORS FORCE
DOI	10.1016/j.jbiomech.2014.05.003
英文摘要	Myocardial contractility is crucial for cardiac output and heart function. But the detailed mechanisms of regulation remain unclear. In the present study, we found that HIP-55, an actin binding protein, negatively regulates myocardial contractility at the single-cell level. HIP-55 was overexpressed and knocked down in cardiomyocytes with an adenovirus infection. The traction forces exerted by single cardiomyocyte were measured using cell traction force microscopy. The results showed that HIP-55 knockdown significantly increased the contractility of the cardiomyocytes and HIP-55 overexpression could markedly reverse this process. Furthermore, HIP-55 was obviously co-localized with F-actin in cardiomyocytes, suggesting that HIP-55 regulated cardiac contractile function through the interaction between HIP-55 and F-actin. This study reveals the regulatory mechanisms of myocardial contractility and provides a new target for preventing and treating cardiovascular disease. (C) 2014 Elsevier Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341462900027&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biophysics; Engineering, Biomedical; SCI(E); EI; PubMed; 1; ARTICLE; cyxiong@pku.edu.cn; lizijian@bjmu.edu.cn; 11; 2715-2720; 47
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189004]
专题	工学院
推荐引用方式 GB/T 7714	Xing, Rui,Li, Shanshan,Liu, Kai,et al. HIP-55 negatively regulates myocardial contractility at the single-cell level[J]. journal of biomechanics,2014.
APA	Xing, Rui.,Li, Shanshan.,Liu, Kai.,Yuan, Yuan.,Li, Qing.,...&Li, Zijian.(2014).HIP-55 negatively regulates myocardial contractility at the single-cell level.journal of biomechanics.
MLA	Xing, Rui,et al."HIP-55 negatively regulates myocardial contractility at the single-cell level".journal of biomechanics (2014).