Plasma and synovial fluid programmed cell death 5 (PDCD5) levels are   inversely associated with TNF-alpha and disease activity in patients   with rheumatoid arthritis

doi:10.3109/1354750X.2012.759277

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	Plasma and synovial fluid programmed cell death 5 (PDCD5) levels are inversely associated with TNF-alpha and disease activity in patients with rheumatoid arthritis
	Wang, Junfeng ; Guan, Zhenpeng ; Ge, Zigang
刊名	biomarkers
	2013
关键词	Disease activity PDCD5 rheumatoid arthritis TNF-alpha GENE-EXPRESSION PROFILES NF-KAPPA-B APOPTOSIS PROTEIN BCL-2 CLASSIFICATION FIBROBLASTS LEUKEMIA CRITERIA FLIP
DOI	10.3109/1354750X.2012.759277
英文摘要	Context: Programmed cell death 5 (PDCD5), a novel apoptotic regulatory gene, has been reported to be associated with rheumatoid arthritis (RA) and osteoarthritis (OA), which can regulate the apoptosis of synoviocytes and chondrocytes cultured in vitro. Objective: To study expression characteristic of PDCD5 in plasma and synovial fluid of RA patients, and analyze its correlation with tumor necrosis factor alpha (TNF-alpha) and disease activity in RA. Methods: A total of 135 subjects were recruited into this study (44 RA patients, 46 OA patients and 45 healthy controls). PDCD5 and TNF-alpha concentrations in plasma and synovial fluid were analyzed by enzyme-linked immunosorbent assay. Results: Plasma and synovial fluid PDCD5 concentrations were significantly elevated in RA patients. Pearson correlation analysis indicated that plasma and synovial fluid PDCD5 levels were inversely correlated with TNF-alpha. Moreover, plasma PDCD5 levels were also inversely correlated with C-reactive protein and erythrocyte sedimentation rate. Conclusion: Plasma and synovial fluid PDCD5 could be useful for monitoring the activity and progression of RA, and its abnormal expression and dysfunction may be correlated to TNF-alpha in RA patients.; Biotechnology & Applied Microbiology; Toxicology; SCI(E); PubMed; 4; ARTICLE; 2; 155-159; 18
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/159318]
专题	工学院
推荐引用方式 GB/T 7714	Wang, Junfeng,Guan, Zhenpeng,Ge, Zigang. Plasma and synovial fluid programmed cell death 5 (PDCD5) levels are inversely associated with TNF-alpha and disease activity in patients with rheumatoid arthritis[J]. biomarkers,2013.
APA	Wang, Junfeng,Guan, Zhenpeng,&Ge, Zigang.(2013).Plasma and synovial fluid programmed cell death 5 (PDCD5) levels are inversely associated with TNF-alpha and disease activity in patients with rheumatoid arthritis.biomarkers.
MLA	Wang, Junfeng,et al."Plasma and synovial fluid programmed cell death 5 (PDCD5) levels are inversely associated with TNF-alpha and disease activity in patients with rheumatoid arthritis".biomarkers (2013).