GATE simulation of a LYSO-based SPECT imager: Validation and detector   optimization

doi:10.1016/j.nima.2014.10.031

CORC > 北京大学 > 工学院

	GATE simulation of a LYSO-based SPECT imager: Validation and detector optimization
	Li, Suying ; Zhang, Qiushi ; Xie, Zhaoheng ; Liu, Qi ; Xu, Baixuan ; Yang, Kun ; Li, Changhui ; Ren, Qiushi
刊名	nuclear instruments methods in physics research section a accelerators spectrometers detectors and associated equipment
	2015
关键词	Monte Carlo simulation Parallel hole collimator Small animal imaging SPELT MONTE-CARLO-SIMULATION GAMMA-CAMERA RESOLUTION PET SYSTEM
DOI	10.1016/j.nima.2014.10.031
英文摘要	This paper presents a small animal SPECT system that is based on cerium doped lutetium yttrium oxyorthosilicate (LYSO) scintillation crystal, position sensitive photomultiplier tubes (PSPMTs) and parallel hole collimator. Spatial resolution test and animal experiment were performed to demonstrate the imaging performance of the detector. Preliminary results indicated a spatial resolution of 2.5 mm at FWHM that cannot meet our design requirement. Therefore, we simulated this gamma camera using GATE (GEANT 4 Application for Tomographic Emission) aiming to make detector spatial resolution less than 2 mm. First, the GATE simulation process was validated through comparison between simulated and experimental data. This also indicates the accuracy and effectiveness of GATE simulation for LYSO-based gamma camera. Then the different detector sampling methods (crystal size with 1.5, and 1 mm) and collimator design (collimator height with 30, 34.8, 38, and 43 mm) were studied to figure out an optimized parameter set. Detector sensitivity changes were also focused on with different parameters set that generated different spatial resolution results. Tradeoff curves of spatial resolution and sensitivity were plotted to determine the optimal collimator height with different sampling methods. Simulation results show that scintillation crystal size of 1 mm and collimator height of 38 min, which can generate a spatial resolution of similar to 1.8 mm and sensitivity of similar to 0.065 cps/kBq, can be an ideal configuration for our SPECT imager design. (C) 2014 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346827700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Instruments & Instrumentation; Nuclear Science & Technology; Physics, Particles & Fields; Spectroscopy; SCI(E); EI; 0; ARTICLE; renqsh@coe.pku.edu.cn; 21-26; 773
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/154095]
专题	工学院
推荐引用方式 GB/T 7714	Li, Suying,Zhang, Qiushi,Xie, Zhaoheng,et al. GATE simulation of a LYSO-based SPECT imager: Validation and detector optimization[J]. nuclear instruments methods in physics research section a accelerators spectrometers detectors and associated equipment,2015.
APA	Li, Suying.,Zhang, Qiushi.,Xie, Zhaoheng.,Liu, Qi.,Xu, Baixuan.,...&Ren, Qiushi.(2015).GATE simulation of a LYSO-based SPECT imager: Validation and detector optimization.nuclear instruments methods in physics research section a accelerators spectrometers detectors and associated equipment.
MLA	Li, Suying,et al."GATE simulation of a LYSO-based SPECT imager: Validation and detector optimization".nuclear instruments methods in physics research section a accelerators spectrometers detectors and associated equipment (2015).