A simulation of current focusing and steering with penetrating optic   nerve electrodes

doi:10.1088/1741-2560/10/6/066007

CORC > 北京大学 > 工学院

	A simulation of current focusing and steering with penetrating optic nerve electrodes
	Li, Menghui ; Yan, Yan ; Wang, Qixin ; Zhao, Honghong ; Chai, Xinyu ; Sui, Xiaohong ; Ren, Qiushi ; Li, Liming
刊名	journal of neural engineering
	2013
关键词	DEEP BRAIN-STIMULATION ELECTRICAL-STIMULATION RETINITIS-PIGMENTOSA CUFF ELECTRODE VISUAL PROSTHESIS GANGLION-CELLS EXTRAOCULAR STIMULATION MORPHOMETRIC-ANALYSIS FELINE RETINA ACTIVATION
DOI	10.1088/1741-2560/10/6/066007
英文摘要	Objective. Current focusing and steering are both widely used to shape the electric field and increase the number of distinct perceptual channels in neural stimulation, yet neither technique has been used for an optic nerve (ON)-based visual prosthesis. In order to evaluate the effects of current focusing and steering in penetrative stimulation, we built an integrated computational model to simulate and investigate the influence of stimulating parameters on ON fibre recruitment. Approach. Finite element models with extremely fine meshes were first established to compute the 3D electric potential distribution under different stimulating parameters. Then the external electric potential was fed to randomized multi-compartment cable models to predict the distribution of fibres generating an action potential. Finally a statistical process was conducted to quantify the recruitment region. Main results. The simulation results show that a two-electrode mode is superior to a three-electrode mode in current steering. The three-electrode mode performs poorly in current focusing, albeit the localized recruitment from both configurations implies that current focusing might be unnecessary in penetrative ON stimulation. Significance. This study provides useful information for the optimized design of penetrating ON electrodes and stimulating strategies. The Monte Carlo style computation paradigm is designed to simulate neural responses of an ensemble of ON fibres, which can be immediately transferred to other similar problems.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000328089000007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Biomedical; Neurosciences; SCI(E); EI; PubMed; 1; ARTICLE; 6; 066007; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153869]
专题	工学院
推荐引用方式 GB/T 7714	Li, Menghui,Yan, Yan,Wang, Qixin,et al. A simulation of current focusing and steering with penetrating optic nerve electrodes[J]. journal of neural engineering,2013.
APA	Li, Menghui.,Yan, Yan.,Wang, Qixin.,Zhao, Honghong.,Chai, Xinyu.,...&Li, Liming.(2013).A simulation of current focusing and steering with penetrating optic nerve electrodes.journal of neural engineering.
MLA	Li, Menghui,et al."A simulation of current focusing and steering with penetrating optic nerve electrodes".journal of neural engineering (2013).