The paracrine effects of adipose-derived stem cells on   neovascularization and biocompatibility of a macroencapsulation device

doi:10.1016/j.actbio.2014.12.025

CORC > 北京大学 > 工学院

	The paracrine effects of adipose-derived stem cells on neovascularization and biocompatibility of a macroencapsulation device
	Wang, Kai ; Yu, Lin-Yang ; Jiang, Li-Yang ; Wang, Hai-Bin ; Wang, Chang-Yong ; Luo, Ying
刊名	acta biomaterialia
	2015
关键词	Adipose-derived stem cell Macroencapsulation Foreign body reaction Angiogenesis Immunomodulation FOREIGN-BODY RESPONSE STROMAL CELLS IMMUNOISOLATION DEVICE SUBCUTANEOUS IMPLANTS REGENERATIVE MEDICINE BIOMATERIALS INFLAMMATION MACROPHAGES ISLETS ENCAPSULATION
DOI	10.1016/j.actbio.2014.12.025
英文摘要	The foreign-body response to biomaterials compromises the performance of many biomedical devices by severe fibrosis and limited neovascularization. Mesenchymal stem cells are known to secrete cytokines for treating inflammatory conditions. In this study, we aim to investigate whether the paracrine products of adipose-derived mesenchymal stem cells (ADSCs) can affect the microenvironment of biomaterials and improve tissue responses to biomaterial implants. A model system was built by loading ADSC spheroids into a macroencapsulation device composed of polytetrafluoroethylene (PTFE) filtration membranes. Soluble ADSC factors that diffused out of the device in vitro promoted the angiogenetic activity of endothelial cells and affected the secretion pattern of macrophages. In vivo study was carried out by subcutaneously embedding blank or ADSC-laden devices in rats. Following a 4 week implantation, the ADSC-laden devices were better vascularized and induced significantly less fibrotic tissue formation in comparison to the non-cellular controls. This study may facilitate our understanding of foreign-body responses and suggest new ways to improve the tissue reaction of biomedical devices for cell-based therapy. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000350520800008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Biomedical; Materials Science, Biomaterials; SCI(E); PubMed; 6; ARTICLE; ying.luo@pku.edu.cn; 65-76; 15
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153807]
专题	工学院
推荐引用方式 GB/T 7714	Wang, Kai,Yu, Lin-Yang,Jiang, Li-Yang,et al. The paracrine effects of adipose-derived stem cells on neovascularization and biocompatibility of a macroencapsulation device[J]. acta biomaterialia,2015.
APA	Wang, Kai,Yu, Lin-Yang,Jiang, Li-Yang,Wang, Hai-Bin,Wang, Chang-Yong,&Luo, Ying.(2015).The paracrine effects of adipose-derived stem cells on neovascularization and biocompatibility of a macroencapsulation device.acta biomaterialia.
MLA	Wang, Kai,et al."The paracrine effects of adipose-derived stem cells on neovascularization and biocompatibility of a macroencapsulation device".acta biomaterialia (2015).