Comparative study on serum levels of macro and trace elements in   schizophrenia based on supervised learning methods

doi:10.1016/j.jtemb.2017.03.010

CORC > 北京大学 > 信息科学技术学院

	Comparative study on serum levels of macro and trace elements in schizophrenia based on supervised learning methods
	Lin, Tong ; Liu, Tiebing ; Lin, Yucheng ; Yan, Lailai ; Chen, Zhongxue ; Wang, Jingyu
刊名	6th International FESTEM Symposium on New Horizons on Trace Elements and Minerals Role in Human and Animal Health
	2017
关键词	Schizophrenia Macro elements Trace elements Supervised learning methods RISK-FACTORS COPPER BIOMARKER SELENIUM ZINC IRON
DOI	10.1016/j.jtemb.2017.03.010
英文摘要	The etiology and pathophysiology of schizophrenia (SCZ) remain obscure. This study explored the associations between SCZ risk and serum levels of 39 macro and trace elements (MTE). A 1:1 matched case-control study was conducted among 114 schizophrenia patients and 114 healthy controls matched by age, sex and region. Blood samples were collected to determine the concentrations of 39 MTE by ICP-AES and ICP-MS. Both supervised learning methods and classical statistical testing were used to uncover the difference of MTE levels between cases and controls. The best prediction accuracies were 99.21% achieved by support vector machines in the original feature space (without dimensionality reduction), and 98.82% achieved by Naive Bayes with dimensionality reduction. More than half of MTE were found to be significantly different between SCZ patients and the controls. The presented investigation showed that there existed remarkable differences in concentrations of MTE between SCZ patients and healthy controls. The results of this study might be useful to diagnosis and prognosis of SCZ; they also indicated other promising applications in pharmacy and nutrition. However, the results should be interpreted with caution due to limited sample size and the lack of potential confounding factors, such as alcohol, smoking, body mass index (BMI), use of antipsychotics and dietary intakes. In the future the application of the analyses will be useful in designs that have larger sample sizes. (C) 2017 Elsevier GmbH. All rights reserved.; National Basic Research 973 Program of China [2011CB302202]; National Natural Science Foundation of China [61375051, 61075119]; Seeding Grant for Medicine and Information Sciences of Peking University [2014-MI-21]; SCI(E); SSCI; ARTICLE; ,SI; 202-208; 43
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/469426]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Lin, Tong,Liu, Tiebing,Lin, Yucheng,et al. Comparative study on serum levels of macro and trace elements in schizophrenia based on supervised learning methods[J]. 6th International FESTEM Symposium on New Horizons on Trace Elements and Minerals Role in Human and Animal Health,2017.
APA	Lin, Tong,Liu, Tiebing,Lin, Yucheng,Yan, Lailai,Chen, Zhongxue,&Wang, Jingyu.(2017).Comparative study on serum levels of macro and trace elements in schizophrenia based on supervised learning methods.6th International FESTEM Symposium on New Horizons on Trace Elements and Minerals Role in Human and Animal Health.
MLA	Lin, Tong,et al."Comparative study on serum levels of macro and trace elements in schizophrenia based on supervised learning methods".6th International FESTEM Symposium on New Horizons on Trace Elements and Minerals Role in Human and Animal Health (2017).