DNAzyme-Based Logic Gate-Mediated DNA Self-Assembly

doi:10.1021/acs.nanolett.5b04608

CORC > 北京大学 > 信息科学技术学院

	DNAzyme-Based Logic Gate-Mediated DNA Self-Assembly
	Zhang, Cheng ; Yang, Jing ; Jiang, Shuoxing ; Liu, Yan ; Yan, Hao
刊名	NANO LETTERS
	2016
关键词	DNA self-assembly DNA origami DNAzyme logic gates NANOSCALE SHAPES FOLDING DNA DESIGN CASCADES CIRCUITS CRYSTALS SIGNAL
DOI	10.1021/acs.nanolett.5b04608
英文摘要	Controlling DNA self-assembly processes using rationally designed logic gates is a major goal of DNA-based nanotechnology and programming. Such controls could facilitate the hierarchical engineering of complex nanopatterns responding to various molecular triggers or inputs. Here, we demonstrate the use of a series of DNAzyme-based logic gates to control DNA tile self-assembly onto a prescribed DNA origami frame. Logic systems such as "YES," "OR," "AND," and "logic switch" are implemented based on DNAzyme-mediated tile recognition with the DNA origami frame. DNAzyme is designed to play two roles: (1) as an intermediate messenger to motivate downstream reactions and (2) as a final trigger to report fluorescent signals, enabling information relay between the DNA origami-framed tile assembly and fluorescent signaling. The results of this study demonstrate the plausibility of DNAzyme-mediated hierarchical self-assembly and provide new tools for generating dynamic and responsive self-assembly systems.; Army Research Office MURI [W911NF-12-1-0420]; National Science Foundation [1334109]; National Natural Science Foundation of China [61272161, 61370099, 61425002, 61320106005, 61571189]; SCI(E); EI; PubMed; ARTICLE; Yan_Liu@asu.edu; Hao.Yan@asu.edu; 1; 736-741; 16
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435969]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Zhang, Cheng,Yang, Jing,Jiang, Shuoxing,et al. DNAzyme-Based Logic Gate-Mediated DNA Self-Assembly[J]. NANO LETTERS,2016.
APA	Zhang, Cheng,Yang, Jing,Jiang, Shuoxing,Liu, Yan,&Yan, Hao.(2016).DNAzyme-Based Logic Gate-Mediated DNA Self-Assembly.NANO LETTERS.
MLA	Zhang, Cheng,et al."DNAzyme-Based Logic Gate-Mediated DNA Self-Assembly".NANO LETTERS (2016).