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	A microchip for in vitro parameter determination of cancer electrochemotherapy
	Wu, Mengxi ; Xiao, Yuan ; Zhao, Deyao ; Liang, Zicai ; Li, Zhihong
	2013
英文摘要	This paper presents a microchip that is used to determine the optimal parameters of cancer electrochemotherapy in vitro rapidly. With a constant concentration of bleomycin, anti-cancer agent, the viability of tumor cells as a function of applied electric field is evaluated. The electric field is localized and linearly varied owing to the design of four-leaf hyperbolic electrodes. Under our experimental condition, MCF-7 (human breast adenocarcinoma) cells are destructively damaged by the synergy of electroper-meabilization and bleomycin when the applied electric field exceeds 4??104 V/m. The optimization in in vitro approaches is of guidance to in vivo applications for electrochemotherapy. ? 2013 IEEE.; EI; 0
语种	英语
DOI标识	10.1109/Transducers.2013.6627229
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/410801]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Wu, Mengxi,Xiao, Yuan,Zhao, Deyao,et al. A microchip for in vitro parameter determination of cancer electrochemotherapy. 2013-01-01.

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