QQ客服 官方微博 反馈留言

	An electroporation chip based on flexible microneedle array for in vivo nucleic acid delivery
	Wei, Zewen ; Wang, Renxing ; Zheng, Shuquan ; Liang, Zicai ; Li, Zhihong
	2014
英文摘要	This paper reports a flexible microneedle array (MNA) electroporation chip for in vivo nucleic acid delivery, which is of great importance for gene therapy. Silicon MNA is proposed to penetrate the high-resistant stratum corneum, while a flexible parylene substrate is used to fit the natural shape of electroporated objects. The chip provides a sufficient electrical field beneath the skin for electroporation with low voltage, which is less likely to harm tissues. Using the proposed chip, we successfully achieved plasmid DNA expression and siRNA delivery in living tissue with low voltage (30-40V). Neither physical nor biological harm to skin was observed. ? 2014 IEEE.; EI; CPCI-S(ISTP); 0
语种	英语
DOI标识	10.1109/MEMSYS.2014.6765766
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/329910]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Wei, Zewen,Wang, Renxing,Zheng, Shuquan,et al. An electroporation chip based on flexible microneedle array for in vivo nucleic acid delivery. 2014-01-01.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。