Metabotropic glutamate subtype 5 receptors modulate fear-conditioning   induced enhancement of prepulse inhibition in rats

doi:10.1016/j.neuropharm.2006.08.016

CORC > 北京大学 > 信息科学技术学院

	Metabotropic glutamate subtype 5 receptors modulate fear-conditioning induced enhancement of prepulse inhibition in rats
	Zou, Dan ; Huang, Juan ; Wu, Xihong ; Li, Liang
刊名	neuropharmacology
	2007
关键词	acoustic startle prepulse inhibition gap detection fear conditioning emotional learning metabotropic glutamate receptors ACOUSTIC STARTLE RESPONSE MGLUR5 ANTAGONIST MPEP LOCOMOTOR-ACTIVITY BASOLATERAL AMYGDALA REFLEX MODIFICATION LATERAL AMYGDALA TEMPORAL ACUITY ANIMAL-MODEL ATTENTIONAL PROCESSES POTENTIATED STARTLE
DOI	10.1016/j.neuropharm.2006.08.016
英文摘要	Non-startling acoustic events presented shortly before an intense startling sound can inhibit the acoustic startle reflex. This phenomenon is called prepulse inhibition (PPI), and is widely used as a model of sensorimotor gating. The present study investigated whether PPI can be modulated by fear conditioning, whose acquisition can be blocked by the specific antagonist of metabotropic glutamate receptors subtype 5 (mGluR5), 2-methyl-6-(phenylethynyl)-pyridine (MPEP). The results show that a gap embedded in otherwise continuous noise sounds, which were delivered by two spatially separated loudspeakers, could inhibit the startle reflex induced by an intense sound that was presented 50 ins after the gap. The inhibitory effect depended on the duration of the gap, and was enhanced by fear conditioning that was introduced by temporally pairing the gap with footshock. Intraperitoneal injection of MPEP (0.5 or 5 mg/kg) 30 min before fear conditioning blocked the enhancing effect of fear conditioning on PPI, but did not affect either the baseline startle magnitude or PPI if no fear conditioning was introduced. These results indicate that PPI is enhanced when the prepulse signifies an aversive event after fear conditioning. Also, mGlu5Rs play a role in preserving the fear-conditioning-induced enhancement of PPI. (c) 2006 Elsevier Ltd. All rights reserved.; Neurosciences; Pharmacology & Pharmacy; SCI(E); PubMed; SSCI; 0; ARTICLE; 2; 476-486; 52
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/198683]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Zou, Dan,Huang, Juan,Wu, Xihong,et al. Metabotropic glutamate subtype 5 receptors modulate fear-conditioning induced enhancement of prepulse inhibition in rats[J]. neuropharmacology,2007.
APA	Zou, Dan,Huang, Juan,Wu, Xihong,&Li, Liang.(2007).Metabotropic glutamate subtype 5 receptors modulate fear-conditioning induced enhancement of prepulse inhibition in rats.neuropharmacology.
MLA	Zou, Dan,et al."Metabotropic glutamate subtype 5 receptors modulate fear-conditioning induced enhancement of prepulse inhibition in rats".neuropharmacology (2007).