MAP4K4 deficiency in CD4(+) T cells aggravates lung damage induced by   ozone-oxidized black carbon particles

doi:10.1016/j.etap.2016.08.006

CORC > 北京大学 > 环境科学与工程学院

	MAP4K4 deficiency in CD4(+) T cells aggravates lung damage induced by ozone-oxidized black carbon particles
	Jin, Ming ; Chu, Hongqian ; Li, Yuan ; Tao, Xi ; Cheng, Zhiyuan ; Pan, Yao ; Meng, Qinghe ; Li, Leilei ; Hou, Xiaohong ; Chen, Yueyue ; Huang, Hongpeng ; Jia, Guang ; Shang, Jing ; Zhu, Tong ; Shang, Lanqin ; Hao, Weidong ; Wei, Xuetao
刊名	ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
	2016
关键词	Ozone-oxidized black carbon MAP4K4 CD4(+) T cell CD4(+)IL17(+) T cell Lung inflammation PARTICULATE MATTER INSULIN-RESISTANCE AIR-POLLUTION KINASE ASSOCIATION ACTIVATION GENERATION DISEASE TRAF2
DOI	10.1016/j.etap.2016.08.006
英文摘要	As the main composition of combustion, black carbon (BC) is becoming more and more noticeable at home and abroad. Ozone-oxidized black carbon (oBC) was produced through aging of ozone, one of the near-surface pollutants, to black carbon. And oBC was found to be more oxidation and cell toxicity when compared with BC. Besides, as a key cell, of immunity, whether CD4(+) T cell would involve in lung inflammation induced by particular matter is still unclear. This study aims to observe the effect of oBC on lung damage in mice and discuss how the functional MAP4K4 defect CD4(+) T cells (conditional knockout of MAP4K4) presents its role in this process. In our study, MAP4K4 deletion in CD4(+) T cells (MAP4K4 cKO) could increase cell number of macrophages, lymphocytes and neutrophils in bronchoalveolar lavage fluid (BALF) exposed to oBC. MAP4K4 deletion in CD4(+) T cell also affected CD4(+) T cell differentiation in mediastinal lymph nodes after oBC stimulation. The number of CD4(+)IL17(+) T cell increased obviously. The levels of IL-6 mRNA of lung in MAP4K4 cKO mice was higher than that in wild type mice after exposed to oBC, while the level of IL-6 in BALF had the same trend. Histological examination showed that MAP4K4 deletion in CD4(+) T cells affected lung inflammation induced by oBC. Results indicated that MAP4K4 cKO in CD4(+) T cells upgraded the level of inflammation in lung when exposed to oBC, which may be connected to the CD4(+) T cell differentiation and JNK, ERK and P38 pathways. (C) 2016 Elsevier B.V. All rights reserved.; National Natural Science Foundation of China [21190051]; SCI(E); PubMed; ARTICLE; weixt1010@gmail.com; 246-254; 46
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/493288]
专题	环境科学与工程学院
推荐引用方式 GB/T 7714	Jin, Ming,Chu, Hongqian,Li, Yuan,et al. MAP4K4 deficiency in CD4(+) T cells aggravates lung damage induced by ozone-oxidized black carbon particles[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2016.
APA	Jin, Ming.,Chu, Hongqian.,Li, Yuan.,Tao, Xi.,Cheng, Zhiyuan.,...&Wei, Xuetao.(2016).MAP4K4 deficiency in CD4(+) T cells aggravates lung damage induced by ozone-oxidized black carbon particles.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY.
MLA	Jin, Ming,et al."MAP4K4 deficiency in CD4(+) T cells aggravates lung damage induced by ozone-oxidized black carbon particles".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2016).