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	MAP4K4 deficiency in CD4~+ T cells aggravates lung damage induced by ozone-oxidized black carbon particles; MAP4K4 deficiency in CD4~+ T cells aggravates lung damage induced by ozone-oxidized black carbon particles
	Ming Jin ; Hongqian Chu ; Yuan Li ; Xi Tao ; Zhiyuan Cheng ; Yao Pan ; Qinghe Meng ; Leilei Li ; Xiaohong Hou ; Yueyue Chen ; Hongpeng Huang ; Guang jia ; Jing Shang ; Tong Zhu ; Lanqin Shang ; Weidong Hao ; Xuetao Wei
	2016
关键词	ozone-oxidized black carbon MAP4K4 CD4~+ T cell CD4~+IL17~+ T cell lung inflammation ozone-oxidized black carbon MAP4K4 CD4~+ T cell CD4~+IL17~+ T cell lung inflammation
英文摘要	As the main composition of combustion,black carbon(BC) is becoming more and more noticeable at home and abroad.Ozone-oxidized black carbon(oBC)was produced through aging of ozone,one of the near-surface pollutants,to black carbon.And oBC was found to be more oxidation and cell toxicity when compared with BC.Besides,as a key cell of immunity,whether CD4~+ T cell would involve in lung inflammation induced by particular matter is still unclear.This study aims to observe the effect of oBC on lung damage in mice and discuss how the functional MAP4K4 defect CD4~+ T cells(conditional knockout of MAP4K4) presents its role in this process.In our study,MAP4K4 deletion in CD4~+ T cells(MAP4K4cKO) could increase cell number of macrophages,lymphocytes and neutrophils in bronchoalveolar lavage fluid(BALF) exposed to oBC.MAP4K4 deletion in CD4~+ T cell also affected CD4~+ T cell differentiation in mediastinal lymph nodes after oBC stimulation.The number of CD4~+ IL17~+ T cell increased obviously.The levels of IL-6mRNA of lu...; As the main composition of combustion,black carbon(BC) is becoming more and more noticeable at home and abroad.Ozone-oxidized black carbon(oBC)was produced through aging of ozone,one of the near-surface pollutants,to black carbon.And oBC was found to be more oxidation and cell toxicity when compared with BC.Besides,as a key cell of immunity,whether CD4~+ T cell would involve in lung inflammation induced by particular matter is still unclear.This study aims to observe the effect of oBC on lung damage in mic; 中国毒理学会免疫毒理专业委员会; 12
语种	英语
出处	第六届中国毒理学会免疫毒理专业委员会换届及学术会议
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/479751]
专题	环境科学与工程学院
推荐引用方式 GB/T 7714	Ming Jin,Hongqian Chu,Yuan Li,et al. MAP4K4 deficiency in CD4~+ T cells aggravates lung damage induced by ozone-oxidized black carbon particles, MAP4K4 deficiency in CD4~+ T cells aggravates lung damage induced by ozone-oxidized black carbon particles. 2016-01-01.

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