The Cardiopulmonary Effects of Ambient Air Pollution and Mechanistic   Pathways: A Comparative Hierarchical Pathway Analysis

doi:10.1371/journal.pone.0114913

CORC > 北京大学 > 环境科学与工程学院

	The Cardiopulmonary Effects of Ambient Air Pollution and Mechanistic Pathways: A Comparative Hierarchical Pathway Analysis
	Roy, Ananya ; Gong, Jicheng ; Thomas, Duncan C. ; Zhang, Junfeng ; Kipen, Howard M. ; Rich, David Q. ; Zhu, Tong ; Huang, Wei ; Hu, Min ; Wang, Guangfa ; Wang, Yuedan ; Zhu, Ping ; Lu, Shou-En ; Ohman-Strickland, Pamela ; Diehl, Scott R. ; Eckel, Sandrah P.
刊名	plos one
	2014
关键词	HEART-RATE-VARIABILITY HEALTHY-YOUNG ADULTS OXIDATIVE STRESS BEIJING OLYMPICS DIESEL EXHAUST CARDIOVASCULAR-DISEASE BLOOD-COAGULATION ELDERLY SUBJECTS TIME-COURSE EXPOSURE
DOI	10.1371/journal.pone.0114913
英文摘要	Previous studies have investigated the associations between exposure to ambient air pollution and biomarkers of physiological pathways, yet little has been done on the comparison across biomarkers of different pathways to establish the temporal pattern of biological response. In the current study, we aim to compare the relative temporal patterns in responses of candidate pathways to different pollutants. Four biomarkers of pulmonary inflammation and oxidative stress, five biomarkers of systemic inflammation and oxidative stress, ten parameters of autonomic function, and three biomarkers of hemostasis were repeatedly measured in 125 young adults, along with daily concentrations of ambient CO, PM2.5, NO2, SO2, EC, OC, and sulfate, before, during, and after the Beijing Olympics. We used a two-stage modeling approach, including Stage I models to estimate the association between each biomarker and pollutant over each of 7 lags, and Stage II mixed-effect models to describe temporal patterns in the associations when grouping the biomarkers into the four physiological pathways. Our results show that candidate pathway groupings of biomarkers explained a significant amount of variation in the associations for each pollutant, and the temporal patterns of the biomarker pollutant-lag associations varied across candidate pathways (p<0.0001) and were not linear (from lag 0 to lag 3: p=0.0629, from lag 3 to lag 6: p=0.0005). These findings suggest that, among this healthy young adult population, the pulmonary inflammation and oxidative stress pathway is the first to respond to ambient air pollution exposure (within 24 hours) and the hemostasis pathway responds gradually over a 2-3 day period. The initial pulmonary response may contribute to the more gradual systemic changes that likely ultimately involve the cardiovascular system.; Multidisciplinary Sciences; SCI(E); PubMed; 0; ARTICLE; eckel@usc.edu; 12; e114913; 9
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188715]
专题	环境科学与工程学院
推荐引用方式 GB/T 7714	Roy, Ananya,Gong, Jicheng,Thomas, Duncan C.,et al. The Cardiopulmonary Effects of Ambient Air Pollution and Mechanistic Pathways: A Comparative Hierarchical Pathway Analysis[J]. plos one,2014.
APA	Roy, Ananya.,Gong, Jicheng.,Thomas, Duncan C..,Zhang, Junfeng.,Kipen, Howard M..,...&Eckel, Sandrah P..(2014).The Cardiopulmonary Effects of Ambient Air Pollution and Mechanistic Pathways: A Comparative Hierarchical Pathway Analysis.plos one.
MLA	Roy, Ananya,et al."The Cardiopulmonary Effects of Ambient Air Pollution and Mechanistic Pathways: A Comparative Hierarchical Pathway Analysis".plos one (2014).