Stress attenuates the flexible updating of aversive value

doi:10.1073/pnas.1702565114

CORC > 北京大学 > 心理与认知科学学院

	Stress attenuates the flexible updating of aversive value
	Raio, Candace M. ; Hartley, Catherine A. ; Orederu, Temidayo A. ; Li, Jian ; Phelps, Elizabeth A.
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2017
关键词	threat stress reversal learning cognitive flexibility computational modeling ACUTE PSYCHOSOCIAL STRESS COGNITIVE FLEXIBILITY LOCUS-COERULEUS HUMAN BRAIN MEMORY MODEL FEAR RESPONSES NEURONS ANXIETY
DOI	10.1073/pnas.1702565114
英文摘要	In a dynamic environment, sources of threat or safety can unexpectedly change, requiring the flexible updating of stimulus-outcome associations that promote adaptive behavior. However, aversive contexts in which we are required to update predictions of threat are often marked by stress. Acute stress is thought to reduce behavioral flexibility, yet its influence on the modulation of aversive value has not been well characterized. Given that stress exposure is a prominent risk factor for anxiety and trauma-related disorders marked by persistent, inflexible responses to threat, here we examined how acute stress affects the flexible updating of threat responses. Participants completed an aversive learning task, in which one stimulus was probabilistically associated with an electric shock, while the other stimulus signaled safety. A day later, participants underwent an acute stress or control manipulation before completing a reversal learning task during which the original stimulus-outcome contingencies switched. Skin conductance and neuroendocrine responses provided indices of sympathetic arousal and stress responses, respectively. Despite equivalent initial learning, stressed participants showed marked impairments in reversal learning relative to controls. Additionally, reversal learning deficits across participants were related to heightened levels of alpha-amylase, a marker of noradrenergic activity. Finally, fitting arousal data to a computational reinforcement learning model revealed that stress-induced reversal learning deficits emerged from stress-specific changes in the weight assigned to prediction error signals, disrupting the adaptive adjustment of learning rates. Our findings provide insight into how stress renders individuals less sensitive to changes in aversive reinforcement and have implications for understanding clinical conditions marked by stress-related psychopathology.; NIH [R01 MH097085]; Henry M. MacCracken Graduate Fellowship; Ministry of Science and Technology of China [2015CB559200]; National Natural Science Foundation of China [31371019]; SCI(E); SSCI; ARTICLE; 42; 11241-11246; 114
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/480269]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Raio, Candace M.,Hartley, Catherine A.,Orederu, Temidayo A.,et al. Stress attenuates the flexible updating of aversive value[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2017.
APA	Raio, Candace M.,Hartley, Catherine A.,Orederu, Temidayo A.,Li, Jian,&Phelps, Elizabeth A..(2017).Stress attenuates the flexible updating of aversive value.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
MLA	Raio, Candace M.,et al."Stress attenuates the flexible updating of aversive value".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017).