Serum ApoB levels in depressive patients: associated with cognitive   deficits

doi:10.1038/srep39992

CORC > 北京大学 > 心理与认知科学学院

	Serum ApoB levels in depressive patients: associated with cognitive deficits
	Hui, Li ; Han, Mei ; Du, Xiang Dong ; Zhang, Bao Hua ; He, Shu Chang ; Shao, Tian Nan ; Yin, Guang Zhong
刊名	SCIENTIFIC REPORTS
	2017
关键词	MAJOR DEPRESSION ALZHEIMERS-DISEASE OXIDATIVE STRESS NEUROPSYCHIATRIC SYMPTOMS WORKING-MEMORY DISORDERS RECURRENT SCHIZOPHRENIA IMPAIRMENT LANGUAGE
DOI	10.1038/srep39992
英文摘要	Cognitive deficits have been regarded as one of the most significant clinical symptoms of depressive disorder. Accumulating evidence has shown that apolipoprotein B (ApoB) levels, which are responsible for inducing neurodegeneration, may be involved in cognitive deficits. This study examines cognitive deficits, and the correlation of serum ApoB levels with cognitive deficits of depressive disorder. 90 depressive patients and 90 healthy controls with matched age and gender were recruited. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Serum ApoB levels in depressive patients were measured by immunoturbidimetric method. Our results showed that depressive patients had lower scores of cognition including RBANS total score and subscales of language and delayed memory (all, p < 0.001) than healthy controls after controlling for the variables. The differences in cognitive functions also passed Bonferroni corrections. Serum ApoB levels were negatively correlated with delayed memory score in depressive patients (r = -0.30, p = 0.01). Furthermore, stepwise multivariate regression analysis indicated that serum ApoB levels independently contributed to delayed memory in depressive patients (t = -2.68, p = 0.01). Our findings support that serum ApoB levels may be involved in delayed memory decline in depressive patients. Depressive patients also experience greater cognitive deficits, especially in delayed memory and language than healthy controls.; Wenzhou Municipal Sci-Tech Bureau Program [H20150008]; Sci-Res Project of Medicine and Health of Wenzhou Municipal [2015B21]; Suzhou Key Diagnosis and Treatment Program [LCZX201316]; Suzhou Sci-Tech Program [SYS201372]; Jiangsu Province Natural Science Fund Project [BK20151197]; Jiangsu Province Scientific and Technological Program [BL2013018]; Suzhou Key Medical Center for Psychiatric Diseases [Szzx201509]; National Natural Science Foundation of China [81501160]; SCI(E); SSCI; ARTICLE; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/469415]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Hui, Li,Han, Mei,Du, Xiang Dong,et al. Serum ApoB levels in depressive patients: associated with cognitive deficits[J]. SCIENTIFIC REPORTS,2017.
APA	Hui, Li.,Han, Mei.,Du, Xiang Dong.,Zhang, Bao Hua.,He, Shu Chang.,...&Yin, Guang Zhong.(2017).Serum ApoB levels in depressive patients: associated with cognitive deficits.SCIENTIFIC REPORTS.
MLA	Hui, Li,et al."Serum ApoB levels in depressive patients: associated with cognitive deficits".SCIENTIFIC REPORTS (2017).