SCHIZOPHRENIA AFFECTS SPEECH-INDUCED FUNCTIONAL CONNECTIVITY OF THE   SUPERIOR TEMPORAL GYRUS UNDER COCKTAIL-PARTY LISTENING CONDITIONS

doi:10.1016/j.neuroscience.2017.06.043

CORC > 北京大学 > 心理与认知科学学院

	SCHIZOPHRENIA AFFECTS SPEECH-INDUCED FUNCTIONAL CONNECTIVITY OF THE SUPERIOR TEMPORAL GYRUS UNDER COCKTAIL-PARTY LISTENING CONDITIONS
	Li, Juanhua ; Wu, Chao ; Zheng, Yingjun ; Li, Ruikeng ; Li, Xuanzi ; She, Shenglin ; Wu, Haibo ; Peng, Hongjun ; Ning, Yuping ; Li, Liang
刊名	NEUROSCIENCE
	2017
关键词	schizophrenia speech perception precedence effect functional connectivity masking superior temporal gyrus PERCEIVED SPATIAL SEPARATION EVENT-RELATED FMRI INFORMATIONAL MASKING CHINESE SPEECH MASKED SPEECH OLDER-ADULTS PERCEPTION RECOGNITION CORTEX INTEGRATION
DOI	10.1016/j.neuroscience.2017.06.043
英文摘要	The superior temporal gyrus (STG) is involved in speech recognition against informational masking under cocktail-party-listening conditions. Compared to healthy listeners, people with schizophrenia perform worse in speech recognition under informational speech-on-speech masking conditions. It is not clear whether the schizophrenia-related vulnerability to informational masking is associated with certain changes in FC of the STG with some critical brain regions. Using sparse-sampling fMRI design, this study investigated the differences between people with schizophrenia and healthy controls in FC of the STG for target-speech listening against informational speech-on speech masking, when a listening condition with either perceived spatial separation (PSS, with a spatial release of informational masking) or perceived spatial co-location (PSC, without the spatial release) between target speech and masking speech was introduced. The results showed that in healthy participants, but not participants with schizophrenia, the contrast of either the PSS or PSC condition against the masker-only condition induced an enhancement of functional connectivity (FC) of the STG with the left superior parietal lobule and the right precuneus. Compared to healthy participants, participants with schizophrenia showed declined FC of the STG with the bilateral precuneus, right SPL, and right supplementary motor area. Thus, FC of the STG with the parietal areas is normally involved in speech listening against informational masking under either the PSS or PSC conditions, and declined FC of the STG in people with schizophrenia with the parietal areas may be associated with the increased vulnerability to informational masking. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China [81671334, 81601168, 31170985]; Planed Science and Technology Projects of Guangzhou [2014Y2-00105]; Guangzhou Municipal Key Discipline in Medicine for Guangzhou Brain Hospital [GBH2014-ZD06, GBH2014-QN04]; Chinese National Key Clinical Program in Psychiatry [201201004]; Beijing Municipal Science & Tech Commission [Z161100002616017]; China Postdoctoral Science Foundation Program [2016T90050]; SCI(E); SSCI; ARTICLE; 248-257; 359
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/468959]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Li, Juanhua,Wu, Chao,Zheng, Yingjun,et al. SCHIZOPHRENIA AFFECTS SPEECH-INDUCED FUNCTIONAL CONNECTIVITY OF THE SUPERIOR TEMPORAL GYRUS UNDER COCKTAIL-PARTY LISTENING CONDITIONS[J]. NEUROSCIENCE,2017.
APA	Li, Juanhua.,Wu, Chao.,Zheng, Yingjun.,Li, Ruikeng.,Li, Xuanzi.,...&Li, Liang.(2017).SCHIZOPHRENIA AFFECTS SPEECH-INDUCED FUNCTIONAL CONNECTIVITY OF THE SUPERIOR TEMPORAL GYRUS UNDER COCKTAIL-PARTY LISTENING CONDITIONS.NEUROSCIENCE.
MLA	Li, Juanhua,et al."SCHIZOPHRENIA AFFECTS SPEECH-INDUCED FUNCTIONAL CONNECTIVITY OF THE SUPERIOR TEMPORAL GYRUS UNDER COCKTAIL-PARTY LISTENING CONDITIONS".NEUROSCIENCE (2017).