A critical role of temporoparietal junction in the integration of   top-down and bottom-up attentional control

doi:10.1002/hbm.22919

CORC > 北京大学 > 心理与认知科学学院

	A critical role of temporoparietal junction in the integration of top-down and bottom-up attentional control
	Wu, Qiong ; Chang, Chi-Fu ; Xi, Sisi ; Huang, I-Wen ; Liu, Zuxiang ; Juan, Chi-Hung ; Wu, Yanhong ; Fan, Jin
刊名	HUMAN BRAIN MAPPING
	2015
关键词	attentional control fMRI interaction tDCS temporoparietal junction DIRECT-CURRENT STIMULATION POSTERIOR PARIETAL CORTEX LATERAL PREFRONTAL CORTEX FRONTAL EYE FIELD HUMAN BRAIN COGNITIVE CONTROL VISUAL-SEARCH INHIBITORY CONTROL NETWORKS TDCS
DOI	10.1002/hbm.22919
英文摘要	Information processing can be biased toward behaviorally relevant and salient stimuli by top-down (goal-directed) and bottom-up (stimulus-driven) attentional control processes respectively. However, the neural basis underlying the integration of these processes is not well understood. We employed functional magnetic resonance imaging (fMRI) and transcranial direct-current stimulation (tDCS) in humans to examine the brain mechanisms underlying the interaction between these two processes. We manipulated the cognitive load involved in top-down processing and stimulus surprise involved in bottom-up processing in a factorial design by combining a majority function task and an oddball paradigm. We found that high cognitive load and high surprise level were associated with prolonged reaction time compared to low cognitive load and low surprise level, with a synergistic interaction effect, which was accompanied by a greater deactivation of bilateral temporoparietal junction (TPJ). In addition, the TPJ displayed negative functional connectivity with right middle occipital gyrus, which is involved in bottom-up processing (modulated by the interaction effect), and the right frontal eye field (FEF), which is involved in top-down control. The enhanced negative functional connectivity between the TPJ and right FEF was accompanied by a larger behavioral interaction effect across subjects. Application of cathodal tDCS over the right TPJ eliminated the interaction effect. These results suggest that the TPJ plays a critical role in processing bottom-up information for top-down control of attention. Hum Brain Mapp 36:4317-4333, 2015. (c) 2015 Wiley Periodicals, Inc.; ADC 973 [2015CB351800]; Natural Science Foundation of China [31371054]; National Social Science Foundation of China [12AZD116]; Ministry of Science and Technology, Taiwan [MOST-103-2410-H-008-023-MY3, MOST-101-2628-H-008-001-MY4]; National Institute of Mental Health of the National Institutes of Health [R01MH094305]; National Natural Science Foundation of China [81328008]; China Scholarship Council; SCI(E); PubMed; ARTICLE; wuyh@pku.edu.cn; chihungjuan@gmail.com; 11; 4317-4333; 36
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/418296]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Wu, Qiong,Chang, Chi-Fu,Xi, Sisi,et al. A critical role of temporoparietal junction in the integration of top-down and bottom-up attentional control[J]. HUMAN BRAIN MAPPING,2015.
APA	Wu, Qiong.,Chang, Chi-Fu.,Xi, Sisi.,Huang, I-Wen.,Liu, Zuxiang.,...&Fan, Jin.(2015).A critical role of temporoparietal junction in the integration of top-down and bottom-up attentional control.HUMAN BRAIN MAPPING.
MLA	Wu, Qiong,et al."A critical role of temporoparietal junction in the integration of top-down and bottom-up attentional control".HUMAN BRAIN MAPPING (2015).