PHARMACOLOGICAL EXPERIMENTAL STUDY OF THE ANTI-DEPRESSANT EFFECT OF   TOTAL SAIKOSAPONINS

doi:10.4314/ajtcam.v11i2.9

CORC > 北京大学 > 心理与认知科学学院

	PHARMACOLOGICAL EXPERIMENTAL STUDY OF THE ANTI-DEPRESSANT EFFECT OF TOTAL SAIKOSAPONINS
	Liu, Yu ; Cao, Chunmei ; Ding, Haijun
刊名	african journal of traditional complementary and alternative medicines
	2014
关键词	total saikosaponins tail suspension test forced swimming test BUPLEURUM-FALCATUM SAPONINS ROOT
DOI	10.4314/ajtcam.v11i2.9
英文摘要	Background: Chai Hu has the hepato-protective, choleretic, anti-tussive, analgesic, anti-inflammatory, anti-viral, hypotensive, hypolipidemic, and anti-tumor pharmacological effects. In this study, the objective of this paper was to study the anti-depressant effect of total saikosaponins. Materials and Methods: Total saikosaponins were extracted by reflux method, and were identified by thin layer chromatography (TLC). The anti-depressant effect of total saikosaponins was investigated in vitro by tail suspension test, forced swimming test, and reserpine antagonism test in mice. Results: Two times of reflux extraction, temperature of 70 degrees C, and extraction time of 4hrs, for each extraction could improve the yield of saikosaponins. Each treatment group (100, 200, and 300 mg/kg), could significantly shorten the immobility time of mice in the tail suspension test in a somewhat dose-dependent manner. The total saikosaponins antagonized the reserpine-induced akinesia, and ptosis in mice. Conclusion: Total saikosaponins have an anti-depressant effect.; Integrative & Complementary Medicine; SCI(E); 0; 2; 280-284; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/323495]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Liu, Yu,Cao, Chunmei,Ding, Haijun. PHARMACOLOGICAL EXPERIMENTAL STUDY OF THE ANTI-DEPRESSANT EFFECT OF TOTAL SAIKOSAPONINS[J]. african journal of traditional complementary and alternative medicines,2014.
APA	Liu, Yu,Cao, Chunmei,&Ding, Haijun.(2014).PHARMACOLOGICAL EXPERIMENTAL STUDY OF THE ANTI-DEPRESSANT EFFECT OF TOTAL SAIKOSAPONINS.african journal of traditional complementary and alternative medicines.
MLA	Liu, Yu,et al."PHARMACOLOGICAL EXPERIMENTAL STUDY OF THE ANTI-DEPRESSANT EFFECT OF TOTAL SAIKOSAPONINS".african journal of traditional complementary and alternative medicines (2014).