Adolescent social isolation influences cognitive function in adult rats

doi:10.3969/j.issn.1673-5374.2013.11.008

CORC > 北京大学 > 心理与认知科学学院

	Adolescent social isolation influences cognitive function in adult rats
	Sheo, Feng ; Han, Xiao ; Sheo, Shuang ; Wang, Weiwen
刊名	neural regeneration research
	2013
关键词	neural regeneration adolescence social isolation latent inhibition brain-derived neurotrophic factor medial prefrontal cortex nucleus accumbens adult cognitive function neurodevelopmental disorders grants-supported paper neuroregeneration BDNF MESSENGER-RNA NEUROTROPHIC FACTOR FEMALE RATS DOPAMINERGIC-NEURONS RECEPTOR EXPRESSION LATENT INHIBITION PREFRONTAL CORTEX BRAIN SCHIZOPHRENIA STRESS
DOI	10.3969/j.issn.1673-5374.2013.11.008
英文摘要	Adolescence is a critical period for neurodevelopment. Evidence from animal studies suggests that isolated rearing can exert negative effects on behavioral and brain development. The present study aimed to investigate the effects of adolescent social isolation on latent inhibition and brain-derived neurotrophic factor levels in the forebrain of adult rats. Male Wistar rats were randomly divided into adolescent isolation (isolated housing, 38-51 days of age) and social groups. Latent inhibition was tested at adulthood. Brain-derived neurotrophic factor levels were measured in the medial prefrontal cortex and nucleus accumbens by an enzyme-linked immunosorbent assay. Adolescent social isolation impaired latent inhibition and increased brain-derived neurotrophic factor levels in the medial prefrontal cortex of young adult rats. These data suggest that adolescent social isolation has a profound effect on cognitive function and neurotrophin levels in adult rats and may be used as an animal model of neurodevelopmental disorders.; Cell Biology; Neurosciences; SCI(E); PubMed; 中国科学引文数据库(CSCD); 0; ARTICLE; 11; 1025-1030; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/323380]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Sheo, Feng,Han, Xiao,Sheo, Shuang,et al. Adolescent social isolation influences cognitive function in adult rats[J]. neural regeneration research,2013.
APA	Sheo, Feng,Han, Xiao,Sheo, Shuang,&Wang, Weiwen.(2013).Adolescent social isolation influences cognitive function in adult rats.neural regeneration research.
MLA	Sheo, Feng,et al."Adolescent social isolation influences cognitive function in adult rats".neural regeneration research (2013).