Early social isolation disrupts latent inhibition and increases dopamine   D2 receptor expression in the medial prefrontal cortex and nucleus   accumbens of adult rats

doi:10.1016/j.brainres.2012.01.058

CORC > 北京大学 > 心理与认知科学学院

	Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats
	Han, Xiao ; Li, Nanxin ; Xue, Xiaofang ; Shao, Feng ; Wang, Weiwen
刊名	脑研究
	2012
关键词	Adolescence Social isolation Latent inhibition Dopamine D2 receptor Medial prefrontal cortex Nucleus accumbens PREPULSE INHIBITION FEMALE RATS SCHIZOPHRENIA STRESS BEHAVIOR MODEL ADOLESCENCE RESPONSES PHARMACOLOGY PERFORMANCE
DOI	10.1016/j.brainres.2012.01.058
英文摘要	Adolescence is a critical period for neurodevelopment. In the present study, we investigated the effects of pen-adolescent social isolation on latent inhibition (LI) and dopamine 02 receptor expression in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) of young adult rats. Male Sprague-Dawley rats were randomly divided into adolescent isolation (ISO; isolated housing, 21-34 days of age) and social housing (SOC) groups. LI was tested at postnatal day 56. After behavioral testing, the number of dopamine D2 receptor-expressing cells was determined using immunohistochemistry. Adolescent social isolation impaired LI and increased the number of cells expressing the D2 receptor in the mPFC and NAc. The results suggest that adolescent social isolation produces profound effects on cognitive and dopaminergic function in adult rats, and could be used as an animal model of various neurodevelopmental disorders. (C) 2012 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000303033300005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 12; ARTICLE; 38-43; 1447
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162824]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Han, Xiao,Li, Nanxin,Xue, Xiaofang,et al. Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats[J]. 脑研究,2012.
APA	Han, Xiao,Li, Nanxin,Xue, Xiaofang,Shao, Feng,&Wang, Weiwen.(2012).Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats.脑研究.
MLA	Han, Xiao,et al."Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats".脑研究 (2012).