Serotonin Affects Movement Gain Control in the Spinal Cord

doi:10.1523/JNEUROSCI.1855-14.2014

CORC > 北京大学 > 心理与认知科学学院

	Serotonin Affects Movement Gain Control in the Spinal Cord
	Wei, Kunlin ; Glaser, Joshua I. ; Deng, Linna ; Thompson, Christopher K. ; Stevenson, Ian H. ; Wang, Qining ; Hornby, Thomas George ; Heckman, Charles J. ; Kording, Konrad P.
刊名	journal of neuroscience
	2014
关键词	efficient control gain control neuromodulation pharmacology serotonin spinal cord MOTOR EVOKED-POTENTIALS INPUT-OUTPUT PROPERTIES SOLEUS H-REFLEX JENDRASSIK MANEUVER DECEREBRATE CAT SYNAPTIC INPUT VOLUNTARY CONTRACTION ALPHA-MOTONEURONS VISUAL-SYSTEM IN-VIVO
DOI	10.1523/JNEUROSCI.1855-14.2014
英文摘要	A fundamental challenge for the nervous system is to encode signals spanning many orders of magnitude with neurons of limited bandwidth. To meet this challenge, perceptual systems use gain control. However, whether the motor system uses an analogous mechanism is essentially unknown. Neuromodulators, such as serotonin, are prime candidates for gain control signals during force production. Serotonergic neurons project diffusely to motor pools, and, therefore, force production by one muscle should change the gain of others. Here we present behavioral and pharmaceutical evidence that serotonin modulates the input-output gain of motoneurons in humans. By selectively changing the efficacy of serotonin with drugs, we systematically modulated the amplitude of spinal reflexes. More importantly, force production in different limbs interacts systematically, as predicted by a spinal gain control mechanism. Psychophysics and pharmacology suggest that the motor system adopts gain control mechanisms, and serotonin is a primary driver for their implementation in force production.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341767800008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 5; ARTICLE; wei.kunlin@pku.edu.cn; 38; 12690-12700; 34
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162737]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Wei, Kunlin,Glaser, Joshua I.,Deng, Linna,et al. Serotonin Affects Movement Gain Control in the Spinal Cord[J]. journal of neuroscience,2014.
APA	Wei, Kunlin.,Glaser, Joshua I..,Deng, Linna.,Thompson, Christopher K..,Stevenson, Ian H..,...&Kording, Konrad P..(2014).Serotonin Affects Movement Gain Control in the Spinal Cord.journal of neuroscience.
MLA	Wei, Kunlin,et al."Serotonin Affects Movement Gain Control in the Spinal Cord".journal of neuroscience (2014).