Human bronchial epithelial cell injuries induced by fine particulate   matter from sandstorm and non-sandstorm periods: Association with   particle constituents

doi:10.1016/j.jes.2015.12.015

CORC > 北京大学 > 城市与环境学院

	Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents
	Wang, Bin ; Li, Ning ; Deng, Furong ; Buglak, Nicholas ; Park, George ; Su, Shu ; Ren, Aiguo ; Shen, Guofeng ; Tao, Shu ; Guo, Xinbiao
刊名	JOURNAL OF ENVIRONMENTAL SCIENCES
	2016
关键词	Sandstorm particles Human bronchial epithelial cells Particle constituents Inflammation Local environmental surroundings ASIAN SAND DUST POLYCYCLIC AROMATIC-HYDROCARBONS DIESEL EXHAUST PARTICLES MURINE LUNG EOSINOPHILIA NATURAL RELOCATION HVNR LOS-ANGELES BASIN AIR-POLLUTION ALLERGIC RHINITIS OXIDATIVE STRESS DESERT DUST
DOI	10.1016/j.jes.2015.12.015
英文摘要	Epidemiological studies have demonstrated the exacerbation of respiratory diseases following sandstorm-derived particulate matter (PM) exposure. The presence of anthropogenic and biological agents on the sandstorm PM and the escalation of PM < 2.5 mu m (PM2.5) pollution in China have led to serious concerns regarding the health effects of PM2.5 during Asian sandstorms. We investigated how changes in PM2.5 composition, as the weather transitioned towards a sandstorm, affected human airway epithelial cells. Six PM2.5 samples covering two sandstorm events and their respective background and transition periods were collected in Baotou, an industrial city near the Gobi Desert in China. PM samples from all three periods had mild cytotoxicity in human bronchial epithelial cell line BEAS-2B, which was positively correlated with the contents of polycyclic aromatic hydrocarbons and several metals. All PM samples potently increased the release of interleukin-6 (IL-6) and interleukin-8 (IL-8). Endotoxin in all samples contributed significantly to the IL-6 response, with only a minor effect on IL-8. Cr was positively correlated with both IL-6 and IL-8 release, while Si was only associated with the increase of IL-6. Our study suggests that local agricultural and industrial surroundings in addition to the sandstorm play important roles in the respiratory effects of sandstorm-derived PM. (C) 2016 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.; Michigan State University [RN031227]; National Natural Science Foundation of China [41390240, 41130754, 30230310, 41401583]; SCI(E); 中国科技核心期刊(ISTIC); ARTICLE; binwangpku@foxmail.com; lining3@msu.edu; lotus321321@126.com; 09; 201-210; 47
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/451306]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Wang, Bin,Li, Ning,Deng, Furong,et al. Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2016.
APA	Wang, Bin.,Li, Ning.,Deng, Furong.,Buglak, Nicholas.,Park, George.,...&Guo, Xinbiao.(2016).Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents.JOURNAL OF ENVIRONMENTAL SCIENCES.
MLA	Wang, Bin,et al."Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents".JOURNAL OF ENVIRONMENTAL SCIENCES (2016).