p,p &apos;-DDE Induces Gonadal Intersex in Japanese Medaka (Oryzias latipes)   at Environmentally Relevant Concentrations: Comparison with o,p &apos;-DDT

doi:10.1021/acs.est.5b05042

CORC > 北京大学 > 城市与环境学院

	p,p '-DDE Induces Gonadal Intersex in Japanese Medaka (Oryzias latipes) at Environmentally Relevant Concentrations: Comparison with o,p '-DDT
	Sun, Jianxian ; Wang, Chen ; Peng, Hui ; Zheng, Guomao ; Zhang, Shiyi ; Hu, Jianying
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2016
关键词	ANDROGEN RECEPTOR ANTAGONIST ROACH RUTILUS-RUTILUS NORTH CHINA TESTIS-OVA BOHAI BAY CHEMICALS DDT ANTIANDROGENS EXPOSURE ESTROGEN
DOI	10.1021/acs.est.5b05042
英文摘要	Previous studies have reported high body burdens of dichlorodiphenyltrichloroethane (DDT) and its metabolites in wild fishes worldwide. This study evaluated the adverse effects of 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) and o,p'-DDT on gonadal development and reproduction by exposing transgenic Japanese medaka (Oryzias latipes) from hatch for 100 days. While both p,p'-DDE and o,p'-DDT induced intersex in male medaka, the lowest observable effective concentration (LOEC) of o,p'-DDT was 57.7 ng/g ww, about 5-fold lower than that (272 ng/g ww) of p,p'-DDE. Since LOECs of both chemicals were comparable to the body concentrations in wild fish, DDT contamination would likely contribute to the occurrence of intersex observed in wild fish. Exposure to o,p'-DDT resulted in much higher expression of vitellogenin in liver of males than p,p'-DDE, accordant with the higher potency of o,p'-DDT than p,p'-DDE to induce intersex. This phenomenon could be partly explained by the significantly elevated levels of 17 beta-estradiol in plasma of males exposed to o,p'-DDT, in addition to its estrogenic activity via the estrogen receptor. Significantly lower fertilization (p = 0.006) and hatchability (p = 0.019) were observed in the 13 intersex males. This study for the first time demonstrated the induction of intersex and reproductive effects of p,p'-DDE and o,p'-DDT at environmentally relevant concentrations.; National Natural Science Foundation of China [41330637, 41171385]; SCI(E); EI; PubMed; ARTICLE; hujy@urban.pku.edu.cn; 1; 462-469; 50
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/436041]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Sun, Jianxian,Wang, Chen,Peng, Hui,et al. p,p '-DDE Induces Gonadal Intersex in Japanese Medaka (Oryzias latipes) at Environmentally Relevant Concentrations: Comparison with o,p '-DDT[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2016.
APA	Sun, Jianxian,Wang, Chen,Peng, Hui,Zheng, Guomao,Zhang, Shiyi,&Hu, Jianying.(2016).p,p '-DDE Induces Gonadal Intersex in Japanese Medaka (Oryzias latipes) at Environmentally Relevant Concentrations: Comparison with o,p '-DDT.ENVIRONMENTAL SCIENCE & TECHNOLOGY.
MLA	Sun, Jianxian,et al."p,p '-DDE Induces Gonadal Intersex in Japanese Medaka (Oryzias latipes) at Environmentally Relevant Concentrations: Comparison with o,p '-DDT".ENVIRONMENTAL SCIENCE & TECHNOLOGY (2016).