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	Induction of vitellogenin gene expression in medaka exposed to glyphosate and potential molecular mechanism
	Xia, Shuang ; Zhao, Yan-Bin ; Yang, Ming-Qi ; Hu, Jian-Ying
刊名	zhongguo huanjing kexuechina environmental science
	2013
英文摘要	To demonstrate the estrogenic activities of glyphosate and clarify the underlying molecular mechanism, 1~3 days old Japanese medaka were exposed to 0.2, 2, 20, 200, 2000 ??g/L of glyphosate for 5 weeks. Transcription levels of vitellogenin (VTG I) and enzyme genes involved in 17??-E2 biosynthesis and metabolism were measured by Q-RT-PCR. While glyphosate markedly up-regulated VTG transcription levels in both female and male fish, the upward trend was inhibited at the high glyphosate concentrations (at 200 ??g/L and 2000 ??g/L for female, at 2000 ??g/L for male). The gender specific molecular mechanism was observed. In female fish, VTG induction would be due to the increase of transcription levels of FSH gene in brain and CYP19A gene in the gonad, and therefore enhancing the biosynthesis of 17??-E2. However in male fish, the inhibited CYP1A, CYP1B and CYP3A transcription levels which would inhibit 17??-E2 metabolism would be the reasonable explanation.; EI; 0; 9; 1656-1663; 33
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/410513]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Xia, Shuang,Zhao, Yan-Bin,Yang, Ming-Qi,et al. Induction of vitellogenin gene expression in medaka exposed to glyphosate and potential molecular mechanism[J]. zhongguo huanjing kexuechina environmental science,2013.
APA	Xia, Shuang,Zhao, Yan-Bin,Yang, Ming-Qi,&Hu, Jian-Ying.(2013).Induction of vitellogenin gene expression in medaka exposed to glyphosate and potential molecular mechanism.zhongguo huanjing kexuechina environmental science.
MLA	Xia, Shuang,et al."Induction of vitellogenin gene expression in medaka exposed to glyphosate and potential molecular mechanism".zhongguo huanjing kexuechina environmental science (2013).

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