The estrogenic effects of benzylparaben at low doses based on   uterotrophic assay in immature SD rats

doi:10.1016/j.fct.2012.11.043

CORC > 北京大学 > 城市与环境学院

	The estrogenic effects of benzylparaben at low doses based on uterotrophic assay in immature SD rats
	Hu, Ying ; Zhang, Zhaobin ; Sun, Libei ; Zhu, Desheng ; Liu, Qingchun ; Jiao, Jian ; Li, Jun ; Qi, Mingwen
刊名	食品与化学品毒理学
	2013
关键词	Estrogenicity Parabens Benzylparaben Endocrine-disrupting chemicals Uterotrophic effect ENDOCRINE-DISRUPTING CHEMICALS PRESERVATIVES PARABENS EXPOSURE
DOI	10.1016/j.fct.2012.11.043
英文摘要	Benzylparaben (BzP), a type of parabens being used as a preservative agent in cosmetics, food, and pharmaceutical products, may be ingested by humans. In this study, we performed an immature uterotrophic assay using Sprague Dawley (SD) rats by intragastric administration to determine the estrogenic effects of BzP and found significant increases in uterine weight with doses of 0.16 mg/kg body weight and higher (P < 0.05). The in vivo estrogenicity of BzP was supported by in vitro results from the human estrogen receptor alpha (hER alpha)-coactivator recruiting assay and in silico molecular docking analysis performed in this study. The in vitro estrogenic activity of BzP can be observed at concentrations of 1.0 x 10(-8) M and higher. Molecular docking analysis showed that BzP fits well into the agonist pocket of hER alpha. The lowest observed effect dose (LOED) (0.16 mg/kg/day) of BzP is much lower than the documented LOEDs of other parabens. Actual risk may exist for people who consume a diet high in BzP or use BzP-laden cosmetics. In addition, we tested the sensitivity of Wistar rats to 17 beta-estradiol by immature uterotrophic assay, and no obvious uterotrophic response was observed in the rats given doses up to 100 mu g/kg body weight. (c) 2012 Elsevier Ltd. All rights reserved.; Food Science & Technology; Toxicology; SCI(E); PubMed; 3; ARTICLE; 69-74; 53
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/160617]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Hu, Ying,Zhang, Zhaobin,Sun, Libei,et al. The estrogenic effects of benzylparaben at low doses based on uterotrophic assay in immature SD rats[J]. 食品与化学品毒理学,2013.
APA	Hu, Ying.,Zhang, Zhaobin.,Sun, Libei.,Zhu, Desheng.,Liu, Qingchun.,...&Qi, Mingwen.(2013).The estrogenic effects of benzylparaben at low doses based on uterotrophic assay in immature SD rats.食品与化学品毒理学.
MLA	Hu, Ying,et al."The estrogenic effects of benzylparaben at low doses based on uterotrophic assay in immature SD rats".食品与化学品毒理学 (2013).