Association between hospital discharge rate for female breast cancer and   residence in a zip code containing hazardous waste sites

doi:10.1016/j.envres.2014.07.005

CORC > 北京大学 > 城市与环境学院

	Association between hospital discharge rate for female breast cancer and residence in a zip code containing hazardous waste sites
	Lu, Xiaoxia ; Lessner, Lawrence ; Carpenter, David O.
刊名	环境研究
	2014
关键词	Breast cancer Volatile organic compounds Persistent organic compounds Zip codes African-Americans PERSISTENT ORGANIC POLLUTANTS CORONARY-HEART-DISEASE POLYCHLORINATED-BIPHENYLS ENVIRONMENTAL-POLLUTANTS GENETIC-POLYMORPHISM CYTOCHROME-P450 1A1 AFRICAN-AMERICAN NORTH-CAROLINA UNITED-STATES WHITE WOMEN
DOI	10.1016/j.envres.2014.07.005
英文摘要	Background: Exposure to chemicals plays a role in risk of breast cancer. However, possible associations between risk of breast cancer and residential proximity to hazardous waste sites (HWSs) have not been reported. Methods: We determined rates of hospital discharge with a diagnosis of female breast cancer in relation to residence in a zip code containing HWSs in New York State (NYS) after adjustment for ethnicity, age, income and urbanicity. Waste exposure was assessed by both the number of waste sites and the type of contaminants. Negative binomial regression was used to test the associations. Results: After controlling for confounders, the hospital discharge rate of breast cancer for women living in zip codes having four or more HWSs or in zip codes having one HWS increased significantly (at the 0.05 level) by 9.1% and 6.4%, as compared to those living in a zip code with no HWS. The association for women living in zip codes having two or three HWSs was not significant. This indicates that the extent of exposure cannot be assessed solely by the number of waste sites. The discharge rate for women living in zip codes containing at least one volatile organic compound (VOC) waste site was significantly increased 5.6% as compared to those living in a zip code without any HWS, while the increases were not significant for women living in zip codes containing waste sites with persistent organic pollutants (POPs) or other contaminants. The significant associations were stronger for African American than Caucasian women and stronger in more urbanized than in rural areas. Conclusions: Residence within a geographic area (defined by zip codes) that includes a hazardous waste site with VOCs is significantly associated with an increased rate of hospitalization for breast cancer, and the association is stronger for African American than Caucasian women and stronger in more urbanized than in rural areas after adjustment for the confounders. (C) 2014 Elsevier Inc. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346817100050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Environmental Sciences; Public, Environmental & Occupational Health; SCI(E); PubMed; 1; ARTICLE; luxx@urban.pku.edu.cn; lessner2011@gmail.com; dcarpenter@albany.edu; ,SI; 375-381; 134
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/160538]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Lu, Xiaoxia,Lessner, Lawrence,Carpenter, David O.. Association between hospital discharge rate for female breast cancer and residence in a zip code containing hazardous waste sites[J]. 环境研究,2014.
APA	Lu, Xiaoxia,Lessner, Lawrence,&Carpenter, David O..(2014).Association between hospital discharge rate for female breast cancer and residence in a zip code containing hazardous waste sites.环境研究.
MLA	Lu, Xiaoxia,et al."Association between hospital discharge rate for female breast cancer and residence in a zip code containing hazardous waste sites".环境研究 (2014).