Cell fate conversion-from the viewpoint of small molecules and lineage   specifiers

doi:10.1111/dom.12717

CORC > 北京大学 > 生命科学学院

	Cell fate conversion-from the viewpoint of small molecules and lineage specifiers
	Zhao, T. ; Li, Y. ; Deng, H.
刊名	DIABETES OBESITY & METABOLISM
	2016
关键词	chemical reprogramming lineage specifiers pluripotency " small molecules PLURIPOTENT STEM-CELLS MOUSE SOMATIC-CELLS DEFINED FACTORS FUNCTIONAL-NEURONS HUMAN FIBROBLASTS PROGENITOR CELLS REPROGRAMMING FACTORS DRUG DISCOVERY SELF-RENEWAL IPS CELLS seesaw model"
DOI	10.1111/dom.12717
英文摘要	Mammalian development was generally considered a naturally unidirectional and irreversible process. However, pioneering work of recent decades has highlighted the plasticity of mammalian cells and implied the possibilities of manipulating cell fate in vitro. Pluripotent stem cells, which hold great potential for regenerative medicine, have been shown to be reprogrammed from differentiated cells either by somatic cell nuclear transfer or by ectopic expression of pluripotency factors. Nevertheless, it remained unknown whether the reprogramming could be accomplished without pluripotency genes. Recent studies show that lineage specifiers play an important role in orchestrating the process of restoring pluripotency by replacing pluripotency-associated transcription factors. Moreover, a combination of small molecules enables the acquisition of pluripotency from somatic cells without any transgenes, offering a tractable platform to precisely dissect the induction and maintenance of cell identity. Here, we will discuss recent scientific advances regarding the cell fate conversion mediated by small molecules or lineage specifiers, especially in the chemically induced somatic cell reprogramming process, and will provide new insights into the intermediate plastic state and "seesaw model" established by chemical approaches during reprogramming.; National Basic Research Program of China (973 Program) [2015CB964703, 2012CB966401]; National Natural Science Foundation of China [91310305, 31521004]; Ministry of Education of China (111 Project); SCI(E); PubMed; REVIEW; hongkui_deng@pku.edu.cn; Suppl 1; 3-9; 18
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/492934]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhao, T.,Li, Y.,Deng, H.. Cell fate conversion-from the viewpoint of small molecules and lineage specifiers[J]. DIABETES OBESITY & METABOLISM,2016.
APA	Zhao, T.,Li, Y.,&Deng, H..(2016).Cell fate conversion-from the viewpoint of small molecules and lineage specifiers.DIABETES OBESITY & METABOLISM.
MLA	Zhao, T.,et al."Cell fate conversion-from the viewpoint of small molecules and lineage specifiers".DIABETES OBESITY & METABOLISM (2016).