The ATPase hCINAP regulates 18S rRNA processing and is essential for   embryogenesis and tumour growth

doi:10.1038/ncomms12310

CORC > 北京大学 > 生命科学学院

	The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth
	Bai, Dongmei ; Zhang, Jinfang ; Li, Tingting ; Hang, Runlai ; Liu, Yong ; Tian, Yonglu ; Huang, Dadu ; Qu, Linglong ; Cao, Xiaofeng ; Ji, Jiafu ; Zheng, Xiaofeng
刊名	Nature Communications
	2016
关键词	DIAMOND-BLACKFAN ANEMIA TRANSLATIONAL CONTROL ADENYLATE KINASE PROTEIN S14 PIN DOMAIN C-MYC BIOGENESIS CANCER TRANSCRIPTION PROGRESSION
DOI	10.1038/ncomms12310
英文摘要	Dysfunctions in ribosome biogenesis cause developmental defects and increased cancer susceptibility; however, the connection between ribosome assembly and tumorigenesis remains unestablished. Here we show that hCINAP (also named AK6) is required for human 18S rRNA processing and 40S subunit assembly. Homozygous CINAP(-/-) mice show embryonic lethality. The heterozygotes are viable and show defects in 18S rRNA processing, whereas no delayed cell growth is observed. However, during rapid growth, CINAP haploinsufficiency impairs protein synthesis. Consistently, hCINAP depletion in fast-growing cancer cells inhibits ribosome assembly and abolishes tumorigenesis. These data demonstrate that hCINAP reduction is a specific rate-limiting controller during rapid growth. Notably, hCINAP is highly expressed in cancers and correlated with a worse prognosis. Genome-wide polysome profiling shows that hCINAP selectively modulates cancer-associated translatome to promote malignancy. Our results connect the role of hCINAP in ribosome assembly with tumorigenesis. Modulation of hCINAP expression may be a promising target for cancer therapy.; National Science Foundation of China [31470754]; Doctoral Fund of the Ministry of Education of China [20130001130003]; Beijing Natural Science Foundation [5152012]; SCI(E); PubMed; ARTICLE; xiaofengz@pku.edu.cn; 12310; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/491772]
专题	生命科学学院
推荐引用方式 GB/T 7714	Bai, Dongmei,Zhang, Jinfang,Li, Tingting,et al. The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth[J]. Nature Communications,2016.
APA	Bai, Dongmei.,Zhang, Jinfang.,Li, Tingting.,Hang, Runlai.,Liu, Yong.,...&Zheng, Xiaofeng.(2016).The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.Nature Communications.
MLA	Bai, Dongmei,et al."The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth".Nature Communications (2016).