Non-homologous end joining: advances and frontiers

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	Non-homologous end joining: advances and frontiers
	Yang Kai ; Guo Rong ; Xu Dongyi
刊名	Acta Biochimica et Biophysica Sinica
	2016
关键词	non-homologous end joining Ku XRCC4 XLF PAXX
英文摘要	DNA double-strand breaks(DSBs) are the most serious form of DNA damage. In human cells, non-homologous end joining(NHEJ) is the major pathway for the repair of DSBs. Different types of DSBs result in different subsets of NHEJ repair strategies. These variations in NHEJ repair strategies depend on numerous elements, such as the flexible recruitment of NHEJ-related proteins, the complexity of the DSB ends, and the spatial- and temporal-ordered formation of the multiprotein complex. On the one hand, current studies of DNA DSBs repair focus on the repair pathway choices between homologous recombination and classic or alternative NHEJ. On the other hand, increasing researches have also deepened the significance and dug into the cross-links between the NHEJ pathway and the area of genome organization and aging. Although remarkable progress has been made in elucidating the underlying principles during the past decades, the detailed mechanism of action in response to different types of DSBs remains largely unknown and needs further evaluation in the future study.; supported in part by the grants from the National Basic Research Program of China,the National Natural Science Foundation of China; 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 7; 632-640; 48
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/478928]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yang Kai,Guo Rong,Xu Dongyi. Non-homologous end joining: advances and frontiers[J]. Acta Biochimica et Biophysica Sinica,2016.
APA	Yang Kai,Guo Rong,&Xu Dongyi.(2016).Non-homologous end joining: advances and frontiers.Acta Biochimica et Biophysica Sinica.
MLA	Yang Kai,et al."Non-homologous end joining: advances and frontiers".Acta Biochimica et Biophysica Sinica (2016).