Propofol inhibits neuronal apotosis by decreasing p53 levels via   upregulating miR-592-5p

CORC > 北京大学 > 生命科学学院

	Propofol inhibits neuronal apotosis by decreasing p53 levels via upregulating miR-592-5p
	Sun, Yunong ; Chen, Zhiya ; Pan, Chuxiong
刊名	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
	2017
关键词	Propofol p53 apoptosis microRNA anesthetics miR-592-5p MICRORNA EXPRESSION RAT HIPPOCAMPUS ANESTHESIA SEVOFLURANE TOXICITY ACTIVATION APOPTOSIS ISCHEMIA PROTECTS LIVER
英文摘要	Propofol is one of a commonly used intravenous anesthetics. Many studies have shown that propofol can protect the cells from apoptosis by regulating different miRNA. In this study, we found that propofol decreased p53 level via upregulating miR-592-5p. The technique used were real time PCR, western blots and luciferase reporter assay. Moreover, we also found that propofol prevented neurons against actinomycin D, extracellular amyloid beta, TNF-alpha and H2O2 treatments. This study shown that miR-592-5p could be regulated by propofol on preventing cell death.; National Science Foundation of China (NSFC) [81301131, 81571037, 81671044]; SCI(E); ARTICLE; 2; 3953-3958; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/476235]
专题	生命科学学院
推荐引用方式 GB/T 7714	Sun, Yunong,Chen, Zhiya,Pan, Chuxiong. Propofol inhibits neuronal apotosis by decreasing p53 levels via upregulating miR-592-5p[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2017.
APA	Sun, Yunong,Chen, Zhiya,&Pan, Chuxiong.(2017).Propofol inhibits neuronal apotosis by decreasing p53 levels via upregulating miR-592-5p.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.
MLA	Sun, Yunong,et al."Propofol inhibits neuronal apotosis by decreasing p53 levels via upregulating miR-592-5p".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE (2017).