A receptor-like protein acts as a specificity switch for the regulation   of stomatal development

doi:10.1101/gad.297580.117

CORC > 北京大学 > 生命科学学院

	A receptor-like protein acts as a specificity switch for the regulation of stomatal development
	Lin, Guangzhong ; Zhang, Liang ; Han, Zhifu ; Yang, Xinru ; Liu, Weijia ; Li, Ertong ; Chang, Junbiao ; Qi, Yijun ; Shpak, Elena D. ; Chai, Jijie
刊名	GENES & DEVELOPMENT
	2017
关键词	biochemical interaction peptide hormones receptor kinases receptor-like protein stomatal development structure SECRETORY PEPTIDE ARABIDOPSIS PLANT KINASES DENSITY MOUTHS TOO SOFTWARE REVEALS PATTERN
DOI	10.1101/gad.297580.117
英文摘要	Stomata are microscopic openings that allow for the exchange of gases between plants and the environment. In Arabidopsis, stomatal patterning is specified by the ERECTA family (ERf) receptor kinases (RKs), the receptor-like protein (RLP) TOO MANY MOUTHS (TMM), and EPIDERMAL PATTERNING FACTOR (EPF) peptides. Here we show that TMM and ER or ER-LIKE1 (ERL1) form constitutive complexes, which recognize EPF1 and EPF2, but the single ERfs do not. TMM interaction with ERL1 creates a binding pocket for recognition of EPF1 and EPF2, indicating that the constitutive TMM-ERf complexes function as the receptors of EPF1 and EPF2. EPFL9 competes with EPF1 and EPF2 for binding to the ERf-TMM complex. EPFL4 and EPFL6, however, are recognized by the single ERfs without the requirement of TMM. In contrast to EPF1,2, the interaction of EPFL4,6 with an ERf is greatly reduced in the presence of TMM. Taken together, our data demonstrate that TMM dictates the specificity of ERfs for the perception of different EPFs, thus functioning as a specificity switch for the regulation of the activities of ERfs.; Projects of International Cooperation and Exchanges National Natural Science Foundation of China [31420103906]; Chinese Ministry of Science and Technology [2015CB910200]; National Natural Science Foundation of China [31421001]; National Science Foundation [IOS-0843340]; SCI(E); ARTICLE; 9; 927-938; 31
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/473657]
专题	生命科学学院
推荐引用方式 GB/T 7714	Lin, Guangzhong,Zhang, Liang,Han, Zhifu,et al. A receptor-like protein acts as a specificity switch for the regulation of stomatal development[J]. GENES & DEVELOPMENT,2017.
APA	Lin, Guangzhong.,Zhang, Liang.,Han, Zhifu.,Yang, Xinru.,Liu, Weijia.,...&Chai, Jijie.(2017).A receptor-like protein acts as a specificity switch for the regulation of stomatal development.GENES & DEVELOPMENT.
MLA	Lin, Guangzhong,et al."A receptor-like protein acts as a specificity switch for the regulation of stomatal development".GENES & DEVELOPMENT (2017).