STING-mediated DNA sensing in cancer immunotherapy

doi:10.1007/s11427-016-9066-0

CORC > 北京大学 > 生命科学学院

	STING-mediated DNA sensing in cancer immunotherapy
	Zhou, Xiang ; Jiang, Zhengfan
刊名	SCIENCE CHINA-LIFE SCIENCES
	2017
关键词	cancer immunotherapy cGAS innate immunity STING tumorigenesis type I interferon CYCLIC GMP-AMP INNATE IMMUNE RECOGNITION I IFN SIGNALS C-DI-GMP CYTOSOLIC DNA ANTITUMOR IMMUNITY 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID TUMOR MICROENVIRONMENT BACTERIAL 2ND-MESSENGER IMMUNOGENIC TUMORS
DOI	10.1007/s11427-016-9066-0
英文摘要	While STING (STimulator of INterferon Genes) has been shown to be essential for cytosolic DNA-triggered innate immune activation, accumulated evidence obtained from various studies suggested that an intrinsic relevance of STING-associated signaling in tumorigenesis can be observed. Also, several clinical trials using immunostimulatory adjuvants, particularly agonistic as well as non-agonistic ligands for STING, have revealed their therapeutic potential not only as vaccine adjuvants but also as anti-tumor agents. However, cases have also been reported where the involvement of STING shows a protective role in tumor growth. Here we summarize recent findings that have pointed towards the STING pathway as an innate immune sensing mechanism driving type I interferon production in the tumor context. Better understanding of this pathway can guide further development of novel immunotherapeutic strategies in the treatment of cancer.; National Natural Science Foundation of China [91129000]; Postdoctoral Fellowship of Peking-Tsinghua Center for Life Sciences; SCI(E); REVIEW; 6; 563-574; 60
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/473014]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhou, Xiang,Jiang, Zhengfan. STING-mediated DNA sensing in cancer immunotherapy[J]. SCIENCE CHINA-LIFE SCIENCES,2017.
APA	Zhou, Xiang,&Jiang, Zhengfan.(2017).STING-mediated DNA sensing in cancer immunotherapy.SCIENCE CHINA-LIFE SCIENCES.
MLA	Zhou, Xiang,et al."STING-mediated DNA sensing in cancer immunotherapy".SCIENCE CHINA-LIFE SCIENCES (2017).