A Central Catecholaminergic Circuit Controls Blood Glucose Levels during   Stress

doi:10.1016/j.neuron.2017.05.031

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	A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress
	Zhao, Zhe ; Wang, Liang ; Gao, Wenling ; Hu, Fei ; Zhang, Juen ; Ren, Yuqi ; Lin, Rui ; Feng, Qiru ; Cheng, Mingxiu ; Ju, Dapeng ; Chi, Qingsheng ; Wang, Dehua ; Song, Sen ; Luo, Minmin ; Zhan, Cheng
刊名	NEURON
	2017
关键词	ROSTRAL VENTROLATERAL MEDULLA LOCUS-COERULEUS BRAIN-STEM PARAVENTRICULAR NUCLEUS GABAERGIC NEURONS FEEDING-BEHAVIOR NEURAL CIRCUITS POMC NEURONS DRIVER LINES C1 NEURONS
DOI	10.1016/j.neuron.2017.05.031
英文摘要	Stress-induced hyperglycemia is a fundamental adaptive response that mobilizes energy stores in response to threats. Here, our examination of the contributions of the central catecholaminergic (CA) neuronal system to this adaptive response revealed that CA neurons in the ventrolateral medulla (VLM) control stress-induced hyperglycemia. Ablation of VLM CA neurons abolished the hyperglycemic response to both physical and psychological stress, whereas chemogenetic activation of these neurons was sufficient to induce hyperglycemia. We further found that CA neurons in the rostral VLM, but not those in the caudal VLM, cause hyperglycemia via descending projections to the spinal cord. Monosynaptic tracing experiments showed that VLM CA neurons receive direct inputs from multiple stress-responsive brain areas. Optogenetic studies identified an excitatory PVN-VLM circuit that induces hyperglycemia. This study establishes the central role of VLM CA neurons in stress-induced hyperglycemia and substantially expands our understanding of the central mechanism that controls glucose metabolism.; MOST [2012CB837701, 2012YQ03026005, 2012CB837703]; NSFC of China [91432114, 31500860]; Beijing Municipal Government; SCI(E); ARTICLE; 1; 138-+; 95
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/472252]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhao, Zhe,Wang, Liang,Gao, Wenling,et al. A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress[J]. NEURON,2017.
APA	Zhao, Zhe.,Wang, Liang.,Gao, Wenling.,Hu, Fei.,Zhang, Juen.,...&Zhan, Cheng.(2017).A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress.NEURON.
MLA	Zhao, Zhe,et al."A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress".NEURON (2017).