Unique Roles of the Non-identical MCM Subunits in DNA Replication   Licensing

doi:10.1016/j.molcel.2017.06.016

CORC > 北京大学 > 生命科学学院

	Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing
	Zhai, Yuanliang ; Li, Ningning ; Jiang, Hanlun ; Huang, Xuhui ; Gao, Ning ; Tye, Bik Kwoon
刊名	MOLECULAR CELL
	2017
关键词	ORIGIN RECOGNITION COMPLEX SINGLE-STRANDED-DNA DOUBLE-HEXAMER SACCHAROMYCES-CEREVISIAE IN-VITRO HELICASE ACTIVATION MOLECULAR-DYNAMICS FORK PROGRESSION BINDING ACTIVITY STRUCTURAL BASIS
DOI	10.1016/j.molcel.2017.06.016
英文摘要	A family of six homologous subunits, Mcm2, -3, -4, -5, -6, and -7, each with its own unique features, forms the catalytic core of the eukaryotic replicative helicase. The necessity of six similar but non-identical subunits has been a mystery since its initial discovery. Recent cryo-EM structures of the Mcm2-7 (MCM) double hexamer, its precursors, and the origin recognition complex (ORC)-Cdc6-Cdt1-Mcm2-7 (OCCM) intermediate showed that each of these subunits plays a distinct role in orchestrating the assembly of the pre-replication complex (pre-RC) by ORC-Cdc6 and Cdt1.; Research Grants Council of Hong Kong [GRF16138716, GRF16104115, GRF16143016, IGN15SC02, AoE/P-705/16]; Ministry of Science and Technology of China [2013CB910404, 2016YFA0500700]; National Natural Science Foundation of China [31422016, 31470722, 31630087]; China Postdoctoral Science Foundation [2017M610013]; Young Elite Scientists Sponsorship Program by CAST; Peking-Tsinghua Center for Life Sciences; SCI(E); REVIEW; 2; 168-179; 67
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/472065]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhai, Yuanliang,Li, Ningning,Jiang, Hanlun,et al. Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing[J]. MOLECULAR CELL,2017.
APA	Zhai, Yuanliang,Li, Ningning,Jiang, Hanlun,Huang, Xuhui,Gao, Ning,&Tye, Bik Kwoon.(2017).Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing.MOLECULAR CELL.
MLA	Zhai, Yuanliang,et al."Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing".MOLECULAR CELL (2017).