Lef1-dependent hypothalamic neurogenesis inhibits anxiety

doi:10.1371/journal.pbio.2002257

CORC > 北京大学 > 生命科学学院

	Lef1-dependent hypothalamic neurogenesis inhibits anxiety
	Xie, Yuanyuan ; Kaufmann, Dan ; Moulton, Matthew J. ; Panahi, Samin ; Gaynes, John A. ; Watters, Harrison N. ; Zhou, Dingxi ; Xue, Hai-Hui ; Fung, Camille M. ; Levine, Edward M. ; Letsou, Anthea ; Brennan, K. C. ; Dorsky, Richard I.
刊名	PLOS BIOLOGY
	2017
关键词	MELANIN-CONCENTRATING HORMONE IN-SITU HYBRIDIZATION GENE-EXPRESSION DEFICIENT MICE CRNA PROBES MOUSE-BRAIN MCH SYSTEM ZEBRAFISH CELL MECHANISMS
DOI	10.1371/journal.pbio.2002257
英文摘要	While innate behaviors are conserved throughout the animal kingdom, it is unknown whether common signaling pathways regulate the development of neuronal populations mediating these behaviors in diverse organisms. Here, we demonstrate that the Wnt/beta-catenin effector Lef1 is required for the differentiation of anxiolytic hypothalamic neurons in zebrafish and mice, although the identity of Lef1-dependent genes and neurons differ between these 2 species. We further show that zebrafish and Drosophila have common Lef1-dependent gene expression in their respective neuroendocrine organs, consistent with a conserved pathway that has diverged in the mouse. Finally, orthologs of Lef1-dependent genes from both zebrafish and mouse show highly correlated hypothalamic expression in marmosets and humans, suggesting co-regulation of 2 parallel anxiolytic pathways in primates. These findings demonstrate that during evolution, a transcription factor can act through multiple mechanisms to generate a common behavioral output, and that Lef1 regulates circuit development that is fundamentally important for mediating anxiety in a wide variety of animal species.; NIH [R01 NS082645, R01 AI112579, R01 NS085413, R01 AI121080]; DoD [CDMRP PR130373]; SCI(E); ARTICLE; 8; 15
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/471690]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xie, Yuanyuan,Kaufmann, Dan,Moulton, Matthew J.,et al. Lef1-dependent hypothalamic neurogenesis inhibits anxiety[J]. PLOS BIOLOGY,2017.
APA	Xie, Yuanyuan.,Kaufmann, Dan.,Moulton, Matthew J..,Panahi, Samin.,Gaynes, John A..,...&Dorsky, Richard I..(2017).Lef1-dependent hypothalamic neurogenesis inhibits anxiety.PLOS BIOLOGY.
MLA	Xie, Yuanyuan,et al."Lef1-dependent hypothalamic neurogenesis inhibits anxiety".PLOS BIOLOGY (2017).