MG53: Biological Function and Potential as a Therapeutic Target

doi:10.1124/mol.117.108241

CORC > 北京大学 > 生命科学学院

	MG53: Biological Function and Potential as a Therapeutic Target
	Zhang, Yan ; Wu, Hong-Kun ; Lv, Fengxiang ; Xiao, Rui-Ping
刊名	MOLECULAR PHARMACOLOGY
	2017
关键词	ISCHEMIA-REPERFUSION INJURY CELL-MEMBRANE REPAIR INSULIN-RECEPTOR SUBSTRATE-1 E3 UBIQUITIN LIGASES SKELETAL-MUSCLE MUSCULAR-DYSTROPHY METABOLIC SYNDROME MOLECULAR REGULATION SIGNALING PATHWAY MYOCARDIAL INJURY
DOI	10.1124/mol.117.108241
英文摘要	MG53 (also known as tripartite motif, TRIM72) is a cardiac and skeletal muscle-specific TRIM-family protein that exhibits multiple biologic functions. First, MG53 participates in plasma membrane repair of the heart, skeletal muscle, and, other tissues. Second, MG53 is essentially involved in the cardioprotection of cardiac ischemic, preconditioning, and postconditioning by activating the PI3K-Akt-GSK3b and ERK1/2 survival signaling pathways. Moreover, systemic delivery of recombinant MG53 protein ameliorates the impact of a range of injury insults on the heart, skeletal muscle, lung, kidney, skin, and brain. It is noteworthy that chronic upregulation of MG53 induces insulin resistance and metabolic diseases, such as type 2 diabetes and its cardiovascular complications, by acting as an E3 ligase to mediate the degradation of insulin receptor and insulin receptor substrate-1. In addition, MG53 negatively regulates myogenesis. In summary, MG53 is a multifunctional protein involved in the vital physiologic and pathologic processes of multiple organs and is a promising therapeutic target for various human diseases. In this review, we comprehensively summarize current research progress on the biologic functions and therapeutic potential of MG53.; National Basic Research Program of China [2013CB531200, 2012CB518000]; National Natural Science Foundation of China [31671177, 81170100, 81370234, 81630008, 81270190, 31521062]; National Science and Technology Major Projects for Major New Drugs Innovation and Development [2013ZX09508104]; SCI(E); REVIEW; 3; 211-218; 92
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/471254]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, Yan,Wu, Hong-Kun,Lv, Fengxiang,et al. MG53: Biological Function and Potential as a Therapeutic Target[J]. MOLECULAR PHARMACOLOGY,2017.
APA	Zhang, Yan,Wu, Hong-Kun,Lv, Fengxiang,&Xiao, Rui-Ping.(2017).MG53: Biological Function and Potential as a Therapeutic Target.MOLECULAR PHARMACOLOGY.
MLA	Zhang, Yan,et al."MG53: Biological Function and Potential as a Therapeutic Target".MOLECULAR PHARMACOLOGY (2017).