miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb

doi:10.1016/j.celrep.2017.08.060

CORC > 北京大学 > 生命科学学院

	miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb
	Chen, Zeyu ; Stelekati, Erietta ; Kurachi, Makoto ; Yu, Sixiang ; Cai, Zhangying ; Manne, Sasikanth ; Khan, Omar ; Yang, Xiaolu ; Wherry, E. John
刊名	CELL REPORTS
	2017
关键词	TRANSCRIPTIONAL ACTIVATION NEGATIVE REGULATION EFFECTOR EXPRESSION PROLIFERATION RESPONSES LEUKEMIA PROMOTES CANCER HOMEOSTASIS
DOI	10.1016/j.celrep.2017.08.060
英文摘要	MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells following acute viral infection. Moreover, miR-150-deficient memory CD8 T cells were more protective upon rechallenge. A key circuit whereby miR150 repressed memory CD8 T cell development through the transcription factor c-Myb was identified. Without miR-150, c-Myb was upregulated and anti-apoptotic targets of c-Myb, such as Bcl-2 and Bcl-xL, were also increased, suggesting a miR-150-cMyb survival circuit during memory CD8 T cell development. Indeed, overexpression of non-repressible c-Myb rescued the memory CD8 T cell defects caused by overexpression of miR-150. Overall, these results identify a key role for miR-150 in memory CD8Tcells through ac-Myb-controlled enhanced survival circuit.; NIH tetramer core; NIH [AI117718, AI105343, AI112521, AI082630, AI115712, AI117950, AI108545]; Parker Institute for Cancer Immunotherapy; SCI(E); ARTICLE; 11; 2584-2597; 20
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/470888]
专题	生命科学学院
推荐引用方式 GB/T 7714	Chen, Zeyu,Stelekati, Erietta,Kurachi, Makoto,et al. miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb[J]. CELL REPORTS,2017.
APA	Chen, Zeyu.,Stelekati, Erietta.,Kurachi, Makoto.,Yu, Sixiang.,Cai, Zhangying.,...&Wherry, E. John.(2017).miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb.CELL REPORTS.
MLA	Chen, Zeyu,et al."miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb".CELL REPORTS (2017).