Identifying new susceptibility genes on dopaminergic and serotonergic   pathways for the framing effect in decision-making

doi:10.1093/scan/nsx062

CORC > 北京大学 > 生命科学学院

	Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making
	Gao, Xiaoxue ; Liu, Jinting ; Gong, Pingyuan ; Wang, Junhui ; Fang, Wan ; Yan, Hongming ; Zhu, Lusha ; Zhou, Xiaolin
刊名	SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
	2017
关键词	framing effect decision-making DDC COMT SLC6A4 GWAS CATECHOL-O-METHYLTRANSFERASE AMINO-ACID DECARBOXYLASE GENOME-WIDE ASSOCIATION TRANSPORTER GENE PRINCIPAL-COMPONENTS RISK-TAKING POLYMORPHISM INFLUENCES MISSING HERITABILITY VAL(158)MET GENOTYPE AFFECTIVE-DISORDERS
DOI	10.1093/scan/nsx062
英文摘要	The framing effect refers the tendency to be risk-averse when options are presented positively but be risk-seeking when the same options are presented negatively during decision-making. This effect has been found to be modulated by the serotonin transporter gene (SLC6A4) and the catechol-o-methyltransferase gene (COMT) polymorphisms, which are on the dopaminergic and serotonergic pathways and which are associated with affective processing. The current study aimed to identify new genetic variations of genes on dopaminergic and serotonergic pathways that may contribute to individual differences in the susceptibility to framing. Using genome-wide association data and the gene-based principal components regression method, we examined genetic variations of 26 genes on the pathways in 1317 Chinese Han participants. Consistent with previous studies, we found that the genetic variations of the SLC6A4 gene and the COMT gene were associated with the framing effect. More importantly, we demonstrated that the genetic variations of the aromatic-L-amino-acid decarboxylase (DDC) gene, which is involved in the synthesis of both dopamine and serotonin, contributed to individual differences in the susceptibility to framing. Our findings shed light on the understanding of the genetic basis of affective decision-making.; National Basic Research Program of China (973 Program) [2015CB856400]; National Natural Science Foundation of China [31630034, 31600928]; SCI(E); SSCI; ARTICLE; 9; 1534-1544; 12
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/468976]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Gao, Xiaoxue,Liu, Jinting,Gong, Pingyuan,et al. Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making[J]. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE,2017.
APA	Gao, Xiaoxue.,Liu, Jinting.,Gong, Pingyuan.,Wang, Junhui.,Fang, Wan.,...&Zhou, Xiaolin.(2017).Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making.SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE.
MLA	Gao, Xiaoxue,et al."Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making".SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE (2017).