Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling   at the Genome Level in Mammals

doi:10.1016/j.cmet.2016.09.009

CORC > 北京大学 > 生命科学学院

	Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals
	Wu, Yaling ; Tang, Dingbin ; Liu, Na ; Xiong, Wei ; Huang, Huanwei ; Li, Yang ; Ma, Zhixiong ; Zhao, Haijiao ; Chen, Peihao ; Qi, Xiangbing ; Zhang, Eric Erquan
刊名	CELL METABOLISM
	2017
关键词	ACUTE MYOCARDIAL-INFARCTION PROLYL HYDROXYLATION INDUCIBLE FACTOR DISEASE BNIP3 METABOLISM APOPTOSIS FEEDBACK NETWORK BIOLOGY
DOI	10.1016/j.cmet.2016.09.009
英文摘要	Circadian regulation is critically important in maintaining metabolic and physiological homeostasis. However, little is known about the possible influence of the clock on physiological abnormalities occurring under pathological conditions. Here, we report the discovery that hypoxia, a condition that causes catastrophic bodily damage, is gated by the circadian clock in vivo. Hypoxia signals conversely regulate the clock by slowing the circadian cycle and dampening the amplitude of oscillations in a dose-dependent manner. ChIP-seq analyses of hypoxia-inducible factor HIF1A and the core clock component BMAL1 revealed crosstalk between hypoxia and the clock at the genome level. Further, severe consequences caused by acute hypoxia, such as those that occur with heart attacks, were correlated with defects in circadian rhythms. We propose that the clock plays functions in fine-tuning hypoxic responses under pathophysiological conditions. We argue that the clock can, and likely should, be exploited therapeutically to reduce the severity of fatal hypoxia-related diseases.; 973 Program from the M.O.S.T. of China [2012CB837702]; Beijing Municipal Government; Chinese "Recruitment Program of Global Youth Experts"; SCI(E); PubMed; ARTICLE; 1; 73-85; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/457303]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wu, Yaling,Tang, Dingbin,Liu, Na,et al. Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals[J]. CELL METABOLISM,2017.
APA	Wu, Yaling.,Tang, Dingbin.,Liu, Na.,Xiong, Wei.,Huang, Huanwei.,...&Zhang, Eric Erquan.(2017).Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals.CELL METABOLISM.
MLA	Wu, Yaling,et al."Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals".CELL METABOLISM (2017).