Tcf4 Controls Neuronal Migration of the Cerebral Cortex through   Regulation of Bmp7

doi:10.3389/fnmol.2016.00094

CORC > 北京大学 > 生命科学学院

	Tcf4 Controls Neuronal Migration of the Cerebral Cortex through Regulation of Bmp7
	Chen, Tianda ; Wu, Qinwei ; Zhang, Yang ; Lu, Tianlan ; Yue, Weihua ; Zhang, Dai
刊名	FRONTIERS IN MOLECULAR NEUROSCIENCE
	2016
关键词	schizophrenia brain development neuronal migration TCF4 Bmp7 PITT-HOPKINS-SYNDROME TRANSCRIPTION FACTOR DIFFERENTIATION SCHIZOPHRENIA PROGENITORS PROTEINS GENES CELLS E2-2
DOI	10.3389/fnmol.2016.00094
英文摘要	Background: Transcription factor 4 (TCF4) is found to be associated with schizophrenia. TCF4 mutations also cause Pitt-Hopkins Syndrome, a neurodevelopmental disorder associated with severe mental retardation. However, the function of TCF4 during brain development remains unclear. Results: Here, we report that Tcf4 is expressed in the developing cerebral cortex. In utero suppression of Tcf4 arrested neuronal migration, leading to accumulation of ectopic neurons in the intermediate zone. Knockdown of Tcf4 impaired leading process formation. Furthermore, Bone Morphogenetic Protein 7 (Bmp7) is upregulated in Tcf4-deficient neurons. In vivo gain of function and rescue experiments demonstrated that Bmp7 is the major downstream effector of Tcf4 required for neuronal migration. Conclusion: Thus, we have uncovered a new Tcf4/Bmp7-dependent mechanism underlying neuronal migration, and provide insights into the pathogenesis of neurodevelopmental disorders.; National Natural Science Foundation of China [81401111]; Beijing Natural Science Foundation [7144259]; Specialized Research Fund for the Doctoral Program of Higher Education [20130001120115]; SCI(E); PubMed; ARTICLE; tiandachen@bjmu.edu.cn; daizhang@bjmu.edu.cn; 94; 9
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/456895]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Chen, Tianda,Wu, Qinwei,Zhang, Yang,et al. Tcf4 Controls Neuronal Migration of the Cerebral Cortex through Regulation of Bmp7[J]. FRONTIERS IN MOLECULAR NEUROSCIENCE,2016.
APA	Chen, Tianda,Wu, Qinwei,Zhang, Yang,Lu, Tianlan,Yue, Weihua,&Zhang, Dai.(2016).Tcf4 Controls Neuronal Migration of the Cerebral Cortex through Regulation of Bmp7.FRONTIERS IN MOLECULAR NEUROSCIENCE.
MLA	Chen, Tianda,et al."Tcf4 Controls Neuronal Migration of the Cerebral Cortex through Regulation of Bmp7".FRONTIERS IN MOLECULAR NEUROSCIENCE (2016).