Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in   Drosophila Photoreceptors

doi:10.1371/journal.pgen.1005764

CORC > 北京大学 > 生命科学学院

	Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors
	Xu, Ying ; An, Futing ; Borycz, Jolanta A. ; Borycz, Janusz ; Meinertzhagen, Ian A. ; Wang, Tao
刊名	PLOS GENETICS
	2015
关键词	RETINAL DEGENERATION BIOGENIC-AMINES NERVOUS-SYSTEM OPTIC LOBES EBONY MELANOGASTER GENE NEUROTRANSMITTER METABOLISM EXPRESSION
DOI	10.1371/journal.pgen.1005764
英文摘要	Histamine is an important chemical messenger that regulates multiple physiological processes in both vertebrate and invertebrate animals. Even so, how glial cells and neurons recycle histamine remains to be elucidated. Drosophila photoreceptor neurons use histamine as a neurotransmitter, and the released histamine is recycled through neighboring glia, where it is conjugated to beta-alanine to form carcinine. However, how carcinine is then returned to the photoreceptor remains unclear. In an mRNA-seq screen for photoreceptor cell-enriched transporters, we identified CG9317, an SLC22 transporter family protein, and named it CarT (Carcinine Transporter). S2 cells that express CarT are able to take up carcinine in vitro. In the compound eye, CarT is exclusively localized to photoreceptor terminals. Null mutations of cart alter the content of histamine and its metabolites. Moreover, null cart mutants are defective in photoreceptor synaptic transmission and lack phototaxis. These findings reveal that CarT is required for histamine recycling at histaminergic photoreceptors and provide evidence for a CarT-dependent neurotransmitter trafficking pathway between glial cells and photoreceptor terminals.; Chinese Ministry of Science [2014CB849700]; NSERC [DIS000065]; SCI(E); ARTICLE; wangtao@nibs.ac.cn; 12; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/445221]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xu, Ying,An, Futing,Borycz, Jolanta A.,et al. Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors[J]. PLOS GENETICS,2015.
APA	Xu, Ying,An, Futing,Borycz, Jolanta A.,Borycz, Janusz,Meinertzhagen, Ian A.,&Wang, Tao.(2015).Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors.PLOS GENETICS.
MLA	Xu, Ying,et al."Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors".PLOS GENETICS (2015).